Evidence map›Paper›PMID 33026463›Full record

Trial reportDiabetologia2021

Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.

Danièle Pacaud, Anita M Nucci, David Cuthbertson, Dorothy J Becker, Suvi M Virtanen, Johnny Ludvigsson, Jorma Ilonen, Mikael Knip, TRIGR investigators

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00179777 (TRIGR - Trial to Reduce IDDM in the Genetically at Risk), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00179777 nacompletednot on this map

TRIGR - Trial to Reduce IDDM in the Genetically at Risk

TypeinterventionalSponsorUniversity of HelsinkiRan2002 to 2017Enrolled5,156ConditionsDiabetes Mellitus, Type 1ArmsHydrolysed infant formula, Nonhydrolysed infant formula
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2022
    Article
  8. Article
  9. The Causes of Insulin Resistance in Type 1 Diabetes Mellitus: Is There a Place for Quaternary Prevention?International journal of environmental research and public health · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Danièle PacaudDepartment of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada. daniele.pacaud@ahs.ca.ORCID 0000-0001-6337-7241
Anita M NucciDepartment of Nutrition, Georgia State University, Atlanta, GA, USA.ORCID 0000-0001-8823-7384
David CuthbertsonPediatrics Epidemiology Center, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-3785-9834
Dorothy J BeckerDivision of Endocrinology, University of Pittsburgh and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1311-351X
Suvi M VirtanenPublic Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-8928-0878
Johnny LudvigssonCrown Princess Victoria Children's Hospital, Region Östergötland and Division of Pediatrics, Department of Clinical Experimental Medicine, Linkoping University, Linkoping, Sweden.ORCID 0000-0003-1695-5234
Jorma IlonenImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0002-9973-2062
Mikael KnipPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-0474-0033
TRIGR investigators
Georgia State University · USLinköping University · SETampere University · FIUniversity of Calgary · CAUniversity of Helsinki · FIUniversity of Pittsburgh · USUniversity of South Florida · USUniversity of Turku · FI

Funding

Trial to Reduce IDDM in the Genetically at Risk (TRIGR) Data Management UnitU01HD051997 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2006 to 2015
$7.1M
Trial to Reduce IDDM in the Genetically at Risk (TRIGR) Data Management UnitR01HD051997 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2016 to 2018
$2.3M
CIHREunice Kennedy Shriver National Institute of Child Health and Human Development HD051997NICHD NIH HHS R01 HD051997NICHD NIH HHS U01 HD051997
6 · The paper itself

Abstract

aims/hypothesisThe aim of this work was to examine the relationship between family history of type 1 diabetes, birthweight, growth during the first 2 years and development of multiple beta cell autoantibodies in children with a first-degree relative with type 1 diabetes and HLA-conferred disease susceptibility.

methodsIn a secondary analysis of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR), clinical characteristics and development of beta cell autoantibodies were compared in relation to family history of type 1 diabetes (mother vs father vs sibling) in 2074 children from families with a single affected family member.

resultsMultiple autoantibodies (≥2 of 5 measured) developed in 277 (13%) children: 107 (10%), 114 (16%) and 56 (18%) born with a mother, father or sibling with type 1 diabetes, respectively (p < 0.001). The HR for time to multiple autoimmunity was 0.54 (95% CI 0.39, 0.75) in offspring of affected mothers (n = 107/1046, p < 0.001) and 0.81 (95% CI 0.59, 1.11) (n = 114/722, p = 0.19) in offspring of affected fathers, compared with participants with a sibling with type 1 diabetes (comparator group n = 56/306). The time to the first autoantibody present (to insulin, GAD, tyrosine phosphatase-related insulinoma-associated 2 molecules, islet cell or zinc transporter 8) was similar in the three groups. Height velocity (z score/year) in the first 24 months was independently associated with developing multiple antibodies in the total cohort (HR 1.31 [95% CI 1.01, 1.70], p = 0.04). A higher birthweight in children born to an affected mother vs affected father or an affected sibling was not related to the risk of multiple autoimmunity. CONCLUSIONS/

interpretationThe risk of developing multiple autoantibodies was lower in children with maternal type 1 diabetes. For the whole group, this risk of developing multiple autoantibodies was independent of birthweight but was greater in those with increased height velocity during the first 2 years of life. However, the risk associated with paternal type 1 diabetes was not linked to differences in birthweight or early growth.

trial registrationClinicalTrials.gov NCT00179777 Graphical abstract.

Indexed as

Genetic Predisposition to DiseaseAutoantibodiesAutoimmunityBirth WeightBody HeightChild, PreschoolCohort StudiesDiabetes Mellitus, Type 1Double-Blind MethodFathersFemaleHLA AntigensHumansInfantInfant, NewbornInsulin-Secreting CellsAutoantibodiesHLA AntigensBeta cell autoimmunityBirthweightFamilial riskFatherGenetic riskLinear growthMotherProbandType 1 diabetes

Identifiers

PMID33026463
PMCPMC7716821
OpenAlexW3092326520

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.