ArticleIntensive care medicine2020
The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19.
Article in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04636671 (Randomized Controlled Trial of Methylprednisolone Versus Dexamethasone in COVID-19 Pneumonia), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Methylprednisolone Versus Dexamethasone in COVID-19 Pneumonia (MEDEAS Trial)
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Interferon-beta offers promising avenues to COVID-19 treatment: a systematic review and meta-analysis of clinical trial studies.Naunyn-Schmiedeberg's archives of pharmacology · 2021Pooled it
- Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids: an updated meta-analysis of randomized clinical trials with trial sequential analysis.Critical care (London, England) · 2021Pooled it
- Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS.Intensive care medicine · 2020Pooled it
- Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial.Pharmacological reports : PR · 2022Trial
- Neutrophil extracellular traps offer a new therapeutic target for elephant endotheliotropic herpes virus-hemorrhagic disease (EEHV-HD).Communications biology · 2026Article
- How inflammation influences psychiatric disease.World journal of psychiatry · 2024Article
- Corticosteroid outcome may be dependent of duration of use in severe COVID-19.The Korean journal of internal medicine · 2023Article
- Review
- A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.Medicina intensiva · 2023Article
- Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study.Scientific reports · 2022Article
- [Noninvasive respiratory support and invasive ventilation in COVID‑19 : Where do we stand today?]Der Anaesthesist · 2022Review
- Usage of compromised lung volume in monitoring steroid therapy on severe COVID-19.Respiratory research · 2022Observational
- Special Issue "Pulmonary and Critical Care Practice in the Pandemic of COVID-19".Journal of clinical medicine · 2022Article
- Awaiting a cure for COVID-19: therapeutic approach in patients with different severity levels of COVID-19.Le infezioni in medicina · 2022Review
- The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section.Journal of infection and public health · 2022Article
- Article
- Post-mortem dissection of COVID-19: a pathogenic role for macrophages?Intensive care medicine · 2021Article
- Effect of Different Corticosteroid Regimens on the Outcome of Severe COVID-19-Related Acute Respiratory Failure. A Retrospective Analysis.Journal of clinical medicine · 2021Article
- Saffron forMetabolism open · 2021Article
- Cytokine adsorption and ECMO in patients with COVID-19.The Lancet. Respiratory medicine · 2021Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.