ArticleCerebral cortex (New York, N.Y. : 1991)2021
Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- A two-system theory of sensory-evoked brain responses.Brain : a journal of neurology · 2026Review
- Conceptual rethinking of whole-body perturbation-evoked potentials as a biomarker of extralemniscal sensory transmission, alertness and arousal.Frontiers in human neuroscience · 2026Article
- The Extralemniscal System Modulates Early Somatosensory Cortical Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Response Attenuates with Decreasing Inter-Onset Intervals Between Sounds in a Natural Soundscape.eNeuro · 2025Article
- Hyper-extralemniscal model of Fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- EEG of the Dancing Brain: Decoding Sensory, Motor, and Social Processes during Dyadic Dance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Trainable bioinspired magnetic sensitivity adaptation using ferromagnetic colloidal assemblies.Cell reports. Physical science · 2024Article
- Cortical signatures of auditory looming bias show cue-specific adaptation between newborns and young adults.Communications psychology · 2024Article
- Article
- Confidence of probabilistic predictions modulates the cortical response to pain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain Responses to Surprising Stimulus Offsets: Phenomenology and Functional Significance.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Towards a unified neural mechanism for reactive adaptive behaviour.Progress in neurobiology · 2021Article
- A Speech-Level-Based Segmented Model to Decode the Dynamic Auditory Attention States in the Competing Speaker Scenes.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Living in rapidly changing environments has shaped the mammalian brain toward high sensitivity to abrupt and intense sensory events-often signaling threats or affordances requiring swift reactions. Unsurprisingly, such events elicit a widespread electrocortical response (the vertex potential, VP), likely related to the preparation of appropriate behavioral reactions. Although the VP magnitude is largely determined by stimulus intensity, the relative contribution of the differential and absolute components of intensity remains unknown. Here, we dissociated the effects of these two components. We systematically varied the size of abrupt intensity increases embedded within continuous stimulation at different absolute intensities, while recording brain activity in humans (with scalp electroencephalography) and rats (with epidural electrocorticography). We obtained three main results. 1) VP magnitude largely depends on differential, and not absolute, stimulus intensity. This result held true, 2) for both auditory and somatosensory stimuli, indicating that sensitivity to differential intensity is supramodal, and 3) in both humans and rats, suggesting that sensitivity to abrupt intensity differentials is phylogenetically well-conserved. Altogether, the current results show that these large electrocortical responses are most sensitive to the detection of sensory changes that more likely signal the sudden appearance of novel objects or events in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.