ArticleCerebral cortex (New York, N.Y. : 1991)2020
Comparison of Surface Area and Cortical Thickness Asymmetry in the Human and Chimpanzee Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- CIVET-Chimp: An automated pipeline for MRI-based cortical surface extraction in chimpanzees.Neuroimage. Reports · 2026Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
- Individual variation in the chimpanzee arcuate fasciculus predicts vocal and gestural communication.Nature communications · 2025Article
- Article
- The Chimpanzee Brainnetome Atlas reveals distinct connectivity and gene expression profiles relative to humans.Innovation (Cambridge (Mass.)) · 2025Article
- The universe is asymmetric, the mouse brain too.Molecular psychiatry · 2025Article
- Comparative Analysis of Human-Chimpanzee Divergence in Brain Connectivity and its Genetic Correlates.bioRxiv : the preprint server for biology · 2024Article
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Systematic cortical thickness and curvature patterns in primates.NeuroImage · 2023Article
- Age differences in cortical thickness and their association with cognition in chimpanzee (Pan troglodytes).Neurobiology of aging · 2023Article
- Neuroanatomical asymmetries in nonhuman primates in the homologs to Broca's and Wernicke's areas: a mini-review.Emerging topics in life sciences · 2022Article
- Heritability and cross-species comparisons of human cortical functional organization asymmetry.eLife · 2022Article
- Structural perisylvian asymmetry in naturally occurring atypical language dominance.Brain structure & function · 2022Article
- Endocranial asymmetry in New World monkeys: a comparative phylogenetic analysis of morphometric data.Brain structure & function · 2022Article
- Altered Microstructural Changes Detected by Diffusion Kurtosis Imaging in Patients With Cognitive Impairment After Acute Cerebral Infarction.Frontiers in neurology · 2022Article
- Evolution of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
Comparative study of the structural asymmetry of the human and chimpanzee brain may shed light on the evolution of language and other cognitive abilities in humans. Here we report the results of vertex-wise and ROI-based analyses that compared surface area (SA) and cortical thickness (CT) asymmetries in 3D MR images obtained for 91 humans and 77 chimpanzees. The human brain is substantially more asymmetric than the chimpanzee brain. In particular, the human brain has 1) larger total SA in the right compared with the left cerebral hemisphere, 2) a global torque-like asymmetry pattern of widespread thicker cortex in the left compared with the right frontal and the right compared with the left temporo-parieto-occipital lobe, and 3) local asymmetries, most notably in medial occipital cortex and superior temporal gyrus, where rightward asymmetry is observed for both SA and CT. There is also 4) a prominent asymmetry specific to the chimpanzee brain, namely, rightward CT asymmetry of precentral cortex. These findings provide evidence of there being substantial differences in asymmetry between the human and chimpanzee brain. The unique asymmetries of the human brain are potential neural substrates for cognitive specializations, and the presence of significant CT asymmetry of precentral gyrus in the chimpanzee brain should be further investigated.
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