ArticleeLife2020
Lack of airway submucosal glands impairs respiratory host defenses.
Open access · goldAbstract read
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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0cells of the map it votes in
30citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways.bioRxiv : the preprint server for biology · 2026Article
- Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Nasal humoral immunity: the first line of protection against respiratory pathogens.ImmunoHorizons · 2026Review
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- Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.Nature biotechnology · 2025Article
- Cellular heterogeneity and patterning strategies as revealed by upper respiratory epithelium single cell atlas.iScience · 2025Article
- X-linked hypohidrotic ectodermal dysplasia associated with gastroesophageal reflux disease.Molecular genetics and metabolism reports · 2025Article
- Functional tissue units in the Human Reference Atlas.Nature communications · 2025Article
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- Development and Initial Characterization of Pigs withbioRxiv : the preprint server for biology · 2024Article
- Dynamic measurement of airway surface liquid volume with anLab on a chip · 2024Article
- Lung repair and regeneration: Advanced models and insights into human disease.Cell stem cell · 2024Review
- INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE.Transactions of the American Clinical and Climatological Association · 2024Review
- Functional Tissue Units in the Human Reference Atlas.bioRxiv : the preprint server for biology · 2023Article
- Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets.BMC research notes · 2023Article
- Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.Respiratory research · 2023Article
- Mucus aberrant properties in CF: Insights from cells and animal models.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Review
- The Role of Ectodysplasin A on the Ocular Surface Homeostasis.International journal of molecular sciences · 2022Review
- MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.Science advances · 2022Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 2 institutions in 1 country.
Lynda S OstedgaardDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Margaret P PriceDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Kristin M WhitworthDivision of Animal Science, University of Missouri, Columbia, United States.
Mahmoud H Abou AlaiwaDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Anthony J FischerDepartment of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Akshaya WarrierDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Melissa SamuelDivision of Animal Science, University of Missouri, Columbia, United States.
Lee D SpateDivision of Animal Science, University of Missouri, Columbia, United States.
Patrick D AllenDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Brieanna M HilkinDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Guillermo S Romano IbarraDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Miguel E Ortiz BezaraDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.ORCID 0000-0002-3573-5416
Brian J GoodellDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Steven E MatherDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Linda S PowersDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Mallory R StroikDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Nicholas D GansemerDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Camilla E HippeeDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Keyan ZareiDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
J Adam GoekenDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Thomas R BusingaDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Eric A HoffmanDepartment of Biomedical Engineering, University of Iowa, Iowa City, United States.ORCID 0000-0001-8456-9437
David K MeyerholzDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.ORCID 0000-0003-1552-3253
Randall S PratherDivision of Animal Science, University of Missouri, Columbia, United States.
David A StoltzDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.
Michael J WelshDepartment of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, United States.ORCID 0000-0002-1646-6206
University of Iowa · USUniversity of Missouri · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5MRespiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MMultidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MPathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6MAirway Alkalinization and Repurposing Tromethamine as a Therapeutic Approach in Cystic FibrosisR01HL136813 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A, ZABNER, JOSEPH · 2017 to 2021
$5.3MTraining in Molecular Virology, Viral Pathogenesis and Viral VectorsT32AI007533 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 1998 to 2026
$2.5MUltra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0MMechanisms of impaired mucociliary transport in CF airway diseaseK08HL135433 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2017 to 2021
$801kInitial Attachment of Bacteria to Mucus Strands in Cystic FibrosisK08HL136927 · NHLBI · UNIVERSITY OF IOWA · PI FISCHER, ANTHONY JOHN · 2017 to 2020
$639kCystic Fibrosis Foundation CFF FISCHE16I0Cystic Fibrosis Foundation CFF STOLTZ16XX0Howard Hughes Medical InstituteNHLBI NIH HHS K08 HL135433NHLBI NIH HHS K08 HL136927NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL136813NHLBI NIH HHS T32 HL007638NIAID NIH HHS T32 AI007533NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337NIH HHS S10 OD018526
Abstract
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans, and disrupted the gene for ectodysplasin (
Indexed as
AnimalsEctodysplasinsExocrine GlandsFemaleGene Knockout TechniquesMaleRespiratory MucosaStaphylococcus aureusSus scrofaEctodysplasinshost defenselungmedicinesus scrofa
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.