Evidence map›Paper›PMID 33026193›Full record

ArticleESC heart failure2020

Incidence of congestive heart failure in rheumatoid arthritis: a review of literature and meta-regression analysis.

Yaser Khalid, Neethi Dasu, Ankit Shah, Keith Brown, Alan Kaell, Adam Levine, Kirti Dasu, Albert Raminfard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Heart failure in autoimmune rheumatic diseases.Rheumatology international · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Yaser KhalidDivision of Internal Medicine, Memorial Healthcare System, Hollywood, FL, 33021, USA.ORCID https://orcid.org/0000-0002-1210-3977
Neethi DasuDivision of Gastroenterology, Jefferson Health System NJ, Stratford, NJ, USA.
Ankit ShahDivision of Cardiology, Rowan School of Osteopathic Medicine at Virtua Lourdes, Stratford, NJ, 08084, USA.
Keith BrownDivision of Internal Medicine, Rowan School of Osteopathic Medicine, Stratford, United States, 08084, USA.
Alan KaellDivisions of Internal Medicine, Rheumatology, and Research, Mather Hospital, Northwell Health, Long Island, NY, 11777, USA.
Adam LevineDivision of Interventional Cardiology, Virtua Health, Cherry Hill, NJ, 08034, USA.
Kirti DasuDivision of Biology, Syracuse University.
Albert RaminfardDivision of Internal Medicine, Mather Hospital.
Rowan University · USJohn T. Mather Memorial Hospital · USMemorial Healthcare System · USNorthwell Health · USSyracuse University · USThomas Jefferson University Hospital · USVirtua Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsRheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder that not only affects peripheral joints but also increases the risk for cardiovascular disease (CVD) and mortality. Heart failure (HF) appears to be one of the most important contributors to the excess mortality risk among patients with RA. We assessed the incidence of HF in patients with RA compared with age-matched and sex-matched non-RA subjects, after accounting for traditional cardiovascular risk factors and clinical ischemic heart disease. METHODS AND

resultsWe performed an aggregate analysis on three studies of RA patients having listed manifestations of HF. We performed a meta-regression analysis to evaluate the incidence of HF in RA patients with increased age and noted for any gender correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using both fixed-effects and random-effects models. In the cumulative analysis of 5, 220, 883 patients, the incidence of HF was noted to be almost two-fold higher in patients with RA compared with a matched control population (OR 1.78, 95% CI 1.22-2.60, P < 0.003), HTN (OR 1.66, 95% CI 1.24-2.23, P < 0.001), and diabetes (OR 1.57, 95% CI 1.36-1.81, P < 0.001). Women had three-fold higher incidence of HF with RA (OR 3.38, 95% CI 2.59-4.40, P < 0.001). On meta-regression, the incidence of HF increased further with older age (coefficient = 0.12, P = 0.0004).

conclusionsOur systematic review that included over 5 million subjects confirms the suspected increased incidence of HF in RA patients. Women have the greatest risk for HF. Our analysis advocates the need for updating the current guidelines to incorporate screening and preventive methods for HF in RA patients.

Indexed as

Cardiovascular diseaseCongestive heart failureFemale genderInflammatory disorderRheumatoid arthritis

Identifiers

PMID33026193
PMCPMC7754742
OpenAlexW3091813939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.