ArticleEMBO reports2020
MiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex.
Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Potential contribution of age-related and methodological factors to limited reproducibility in autism spectrum disorder blood miRNA biomarker studies: an exploratory meta-analysis.Scientific reports · 2026Pooled it
- MicroRNA-29 acutely regulates memory stability, expression of synaptic genes, and DNA methylation in the mouse adult hippocampus.Cellular and molecular life sciences : CMLS · 2026Article
- Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex.Neuroscience bulletin · 2025Review
- Orchestrating the Matrix: The Role of Glial Cells and Systemic Signals in Perineuronal Net Dynamics.Neurochemical research · 2025Review
- Analysis of microRNA expression reveals convergent evolution of the molecular control of diapause in annual killifishes.Frontiers in genetics · 2025Article
- miR-29 is an important driver of aging-related phenotypes.Communications biology · 2024Article
- Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells.Cell reports. Medicine · 2024Article
- Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.iScience · 2024Article
- Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence.International journal of molecular sciences · 2024Review
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- GDNF and miRNA-29a as biomarkers in the first episode of psychosis: uncovering associations with psychosocial factors.Frontiers in psychiatry · 2024Article
- Visual Cortical Plasticity: Molecular Mechanisms as Revealed by Induction Paradigms in Rodents.International journal of molecular sciences · 2023Review
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Article
- Non-Cell-Autonomous Factors Implicated in Parvalbumin Interneuron Maturation and Critical Periods.Frontiers in neural circuits · 2022Review
- Extracellular Vesicles and HIV-Associated Neurocognitive Disorders: Implications in Neuropathogenesis and Disease Diagnosis.Neurotoxicity research · 2021Review
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- Multisensory Integration: Is Medial Prefrontal Cortex Signaling Relevant for the Treatment of Higher-Order Visual Dysfunctions?Frontiers in molecular neuroscience · 2021Review
- Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 5 countries.
Funding
Abstract
Visual cortical circuits show profound plasticity during early life and are later stabilized by molecular "brakes" limiting excessive rewiring beyond a critical period. The mechanisms coordinating the expression of these factors during the transition from development to adulthood remain unknown. We found that miR-29a expression in the visual cortex dramatically increases with age, but it is not experience-dependent. Precocious high levels of miR-29a blocked ocular dominance plasticity and caused an early appearance of perineuronal nets. Conversely, inhibition of miR-29a in adult mice using LNA antagomirs activated ocular dominance plasticity, reduced perineuronal nets, and restored their juvenile chemical composition. Activated adult plasticity had the typical functional and proteomic signature of critical period plasticity. Transcriptomic and proteomic studies indicated that miR-29a manipulation regulates the expression of plasticity brakes in specific cortical circuits. These data indicate that miR-29a is a regulator of the plasticity brakes promoting age-dependent stabilization of visual cortical connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.