Evidence map›Paper›PMID 33026128›Full record

ArticleJournal of veterinary internal medicine2020

Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs.

Matthew S Miller, Adam J Rudinsky, Brett G Klamer, Dennis J Chew, Valerie J Parker

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew S MillerDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Adam J RudinskyDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-5369-3152
Brett G KlamerCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
Dennis J ChewDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Valerie J ParkerDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-6505-8068
The Ohio State University · US

Funding

National Institutes of Health National Center for Advancing Translational Sciences UL1TR001070
6 · The paper itself

Abstract

backgroundProteinuria has been associated with progression of renal disease and increased morbidity and mortality in dogs and people. In people, proteinuria also has been associated with hypovitaminosis D. Little is known about the relationship between vitamin D metabolism and proteinuria in dogs.

objectivesTo further elucidate vitamin D status in dogs with protein-losing nephropathy (PLN) and minimal to no azotemia. We hypothesized that vitamin D metabolites would be lower in dogs with PLN compared to healthy dogs. ANIMALS: Twenty-three client-owned adult dogs with PLN and 10 healthy control dogs.

methodsSerum 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D (1,25[OH]

resultsCompared to healthy dogs, dogs with PLN had lower concentrations of all vitamin D metabolites (P < .01). Correlations (rho; 95% confidence interval [CI]) in dogs with PLN are reported. Serum 25(OH)D and 24,25(OH) CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PLN have decreased serum concentrations of vitamin D metabolites. Urine 25(OH)D-to-creatinine ratio and UPC are correlated in PLN dogs. Future studies are needed to assess additional management strategies for dogs with PLN.

Indexed as

Dog DiseasesVitamin D DeficiencyAnimalsDogsProteinuriaVitamin DVitamin D-Binding ProteinVitamin DVitamin D-Binding Protein25-hydroxyvitamin Dcalcitriolkidney diseaseurine protein:creatinine

Identifiers

PMID33026128
PMCPMC7694856
OpenAlexW3091878597

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.