ArticleMolecular & general genetics : MGG1987
Conditionally lethal tubA alpha-tubulin mutations in Aspergillus nidulans.
Article in Molecular & general genetics : MGG, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes.Molecular biology of the cell · 2023Article
- Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions.Frontiers in cell and developmental biology · 2022Review
- TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest.Molecular biology of the cell · 2003Article
- Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes.Molecular biology of the cell · 2001Article
- A mutation in gamma-tubulin alters microtubule dynamics and organization and is synthetically lethal with the kinesin-like protein pkl1p.Molecular biology of the cell · 2000Article
- An alpha tubulin mutation suppresses nuclear migration mutations in Aspergillus nidulans.Genetics · 1995Article
- Aspergillus nidulans apsA (anucleate primary sterigmata) encodes a coiled-coil protein required for nuclear positioning and completion of asexual development.The Journal of cell biology · 1995Article
- Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.Genetics · 1994Article
- Either alpha-tubulin isogene product is sufficient for microtubule function during all stages of growth and differentiation in Aspergillus nidulans.Molecular and cellular biology · 1993Article
- Genetic interactions among Chlamydomonas reinhardtii mutations that confer resistance to anti-microtubule herbicides.Genetics · 1992Article
- Rhizoxin resistant mutants with an altered beta-tubulin gene in Aspergillus nidulans.Molecular & general genetics : MGG · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We have mapped 17 extragenic suppressors of benA33, a heat-sensitive beta-tubulin mutation of Aspergillus nidulans, to the tubA alpha tubulin locus. Fifteen of these tubA mutations cause cold sensitivity in a genetic background with benA33 and appear to cause lethality in a background with the wild-type benA allele. We examined the microtubule-mediated processes, nuclear division and nuclear migration, in seven different cold-sensitive double mutants, each carrying benA33 and a different cold-sensitive tubA allele. Nuclear division and migration were inhibited at a restrictive temperature in each case, suggesting that cold sensitivity is due to the inhibition of microtubule function at low temperatures. A single allele, tubA4, suppressed the heat sensitivity conferred by benA33 but did not confer cold sensitivity in a benA33 background, however in a wild-type benA background, tubA4 conferred supersensitivity to antimicrotubule agents and weak cold sensitivity. TubA4 did not suppress the heat sensitivity conferred by two other benA alleles. The cold sensitivity conferred by tubA4 was suppressed by the microtubule stabilizing agent deuterium oxide, and the suppression of heat sensitivity conferred by four other tubA mutations was reversed by deuterium oxide. These results suggest that these mutations may affect hydrophobic interactions between alpha- and beta-tubulin.
Indexed as
Identifiers
3302605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.