Evidence map›Paper›PMID 33025723›Full record

ArticleJournal of medical radiation sciences2021

Intrafraction cone beam computed tomography verification of breath hold during liver stereotactic radiation therapy.

Elizabeth Brown, Erika Muscat, Patrick O'Connor, Howard Liu, Yoo-Young Lee, David Pryor

Open access · goldAbstract read
In one paragraph

Article in Journal of medical radiation sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Elizabeth BrownRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-8360-0578
Erika MuscatRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Patrick O'ConnorRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Howard LiuRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Yoo-Young LeeRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
David PryorRadiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0003-2574-2476
The University of Queensland · AUPrincess Alexandra Hospital · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntrafraction imaging is an Elekta feature that enables cone beam computed tomography (CBCT) acquisition simultaneously with treatment arc delivery. It has facilitated the introduction of breath-hold (BH) gated stereotactic body radiation therapy (SBRT) by enabling visualisation of tumour and organs at risk during treatment. The aims of this study were to assess BH reproducibility and use intrafraction CBCT (IF-CBCT) to quantify any variation in diaphragm position (diaphragmatic feathering) during the multiple BHs performed during each arc.

methodsIF-CBCTs for consecutive liver SBRT patients where BH was achieved using the Elekta Active Breathing Control (ABC) system were retrospectively evaluated. Average intrafraction couch shifts for deep-inspiration BH (DIBH) or end-expiration BH (EEBH) were recorded as an indication of reproducibility. Diaphragmatic feathering was quantified by measuring the difference between the most superior and inferior visible edges of the diaphragm on IF-CBCTs.

resultsA total of 212 images from 30 patients were reviewed. Twenty-two (73.3%) patients were treated in EEBH. The mean intrafraction shift was similar between DIBH and EEBH groups with the largest mean shift of 0.22cm occurring in the superior-inferior direction. Mean diaphragmatic feathering was similar between the DIBH and EEBH groups, 0.09cm (0-0.44cm) and 0.14cm (0-1.89cm) respectively. A higher percentage of EEBH patients demonstrated no diaphragmatic feathering throughout treatment compared with DIBH patients (31.8% vs 25%).

conclusionThe results of this study indicate that BH is reproducible in both DIBH and EEBH for liver SBRT treatment using the ABC system. Appropriate patient selection and BH coaching prior to CT simulation are critical to its success.

Indexed as

Breath HoldingCone-Beam Computed TomographyLiver NeoplasmsRadiosurgeryAgedAged, 80 and overDiaphragmDose Fractionation, RadiationFemaleHumansLiverMaleMiddle AgedReproducibility of ResultsRetrospective Studies

Identifiers

PMID33025723
PMCPMC7890922
OpenAlexW3091982865

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.