Evidence map›Paper›PMID 33025649›Full record

ArticleBritish journal of clinical pharmacology2021

Monitoring the tacrolimus concentration in peripheral blood mononuclear cells of kidney transplant recipients.

Marith I Francke, Dennis A Hesselink, Yi Li, Birgit C P Koch, Lucia E A de Wit, Ron H N van Schaik, Lin Yang, Carla C Baan, Teun van Gelder, Brenda C M de Winter

Open access · hybridAbstract read
In one paragraph

Article in British journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Tacrolimus-why pharmacokinetics matter in the clinic.Frontiers in transplantation · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Marith I FranckeDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Dennis A HesselinkDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Yi LiDepartment of Laboratory Medicine, Research Center of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Birgit C P KochDepartment of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.ORCID 0000-0002-1202-3643
Lucia E A de WitDepartment of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Lin YangDepartment of Pharmacy, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, China.
Carla C BaanDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Teun van GelderDepartment of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Brenda C M de WinterDepartment of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Erasmus MC · NLCodarts Rotterdam · NLFujian Medical University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTacrolimus is a critical dose drug and to avoid under- and overexposure, therapeutic drug monitoring is standard practice. However, rejection and drug-related toxicity occur despite whole-blood tacrolimus pre-dose concentrations ([Tac]

methodsA total of 175 renal transplant recipients were prospectively followed. [Tac]

resultsCorrelations between [Tac]

conclusionsThe correlation between [Tac]

Indexed as

Kidney TransplantationTacrolimusCytochrome P-450 CYP3AGenotypeHumansImmunosuppressive AgentsLeukocytes, MononuclearPolymorphism, Single NucleotideTransplant RecipientsCytochrome P-450 CYP3AImmunosuppressive AgentsTacrolimuskidney transplantationperipheral blood mononuclear cellpharmacogeneticstacrolimustherapeutic drug monitoring

Identifiers

PMID33025649
PMCPMC8056738
OpenAlexW3092043401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.