ArticleMolecular biology reports2020
A novel freshwater cyanophage vB_MelS-Me-ZS1 infecting bloom-forming cyanobacterium Microcystis elabens.
Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Genetic engineering of cyanophages for harmful cyanobacterial bloom treatment-A mini review.Synthetic and systems biotechnology · 2027Review
- Impact of Climate Change on Cyanobacteria-Cyanophage Interactions and Their Role in Cyanobacterial Blooms in Freshwater Lakes.Global change biology · 2026Article
- Identification and characterization of a novel plaque-invisible lytic single-stranded RNA phage.Journal of virology · 2025Article
- Tracking putativemSystems · 2025Article
- Co-Occurrence of Toxic Bloom-Forming CyanobacteriaToxins · 2025Article
- Cyanophage Engineering for Algal Blooms Control.Viruses · 2024Review
- Biotechnological approaches for suppressing Microcystis blooms: insights and challenges.Applied microbiology and biotechnology · 2024Review
- Efficient Broad-Spectrum Cyanophage Function Module Mining.Microorganisms · 2024Article
- A novel Queuovirinae lineage of Pseudomonas aeruginosa phages encode dPreQ0 DNA modifications with a single GA motif that provide restriction and CRISPR Cas9 protection in vitro.Nucleic acids research · 2023Article
- Enrichment Culture but Not Metagenomic Sequencing Identified a Highly Prevalent Phage InfectingMicrobiology spectrum · 2023Article
- Genomic Analysis of a New Freshwater Cyanophage Lbo240-yong1 Suggests a New Taxonomic Family of Bacteriophages.Viruses · 2023Article
- Ecological Dynamics of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2023Article
- Biological and Genomic Characteristics of MaMV-DH01, a Novel FreshwaterMicrobiology spectrum · 2023Article
- Factors driving the halophyte rhizosphere bacterial communities in coastal salt marshes.Frontiers in microbiology · 2023Article
- Multi-year molecular quantification and 'omics analysis ofFrontiers in microbiology · 2023Article
- Incorporating Microbial Species Interaction in Management of Freshwater Toxic Cyanobacteria: A Systems Science Challenge.Aquatic ecology · 2022Article
- Genome sequence of the novel freshwater Microcystis cyanophage Mwe-Yong1112-1.Archives of virology · 2022Article
- Article
- Comparative genomic analysis of five freshwater cyanophages and reference-guided metagenomic data mining.Microbiome · 2022Article
- Article
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8 authors.
Funding
Abstract
Blooms of cyanobacteria cause enormous losses in both the economy and environment. Cyanophages are of great potential for fighting blooming cyanobacteria. Research report on cyanophage of bloom-forming cyanobacterium, Microcystis elabens is deficient. vB_MelS-Me-ZS1 (abbreviated as Me-ZS1) was isolated from fresh water by double-layer agar plate method using M. elabens. TEM exhibited that cyanosiphovirus Me-ZS1 has an icosahedral head about 60 nm in diameter, and a noncontractile tail approximately 260 nm. Experimental infection against 15 cyanobacterial strains showed that Me-ZS1 can infect 12 strains across taxonomic orders (Chroococcales, Nostocales and Oscillatoriales). High-throughput sequencing and bioinformatics analysis revealed that Me-ZS1 has a double-stranded DNA genome of 49,665 bp, with a G + C content of 58.22%, and 73 predicted open reading frames (ORFs). BLASTn and ORF comparisons showed that Me-ZS1 shares very low homology with the public sequences, and the phylogenetic tree based on TerL indicated that Me-ZS1 may delegate a novel and genetically distinct clade of Siphoviridae phages. In microcosm experiment, Me-ZS1 represented apparent effect on reducing relative abundance of cyanobacteria, increasing relative abundance of Saprospiraceae and protecting brocade carp (Carassius auratus) in cyanobacterial bloom water. This study isolated and characterized a novel broad-host-range Microcystis phage Me-ZS1 presenting a genetically distinct clade of freshwater cyanophage. The features of cyanophage Me-ZS1 provide a potential solution to the loss caused by cyanobacterial bloom.
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