Evidence map›Paper›PMID 33025403›Full record

SynthesisJournal of assisted reproduction and genetics2020

Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review.

Giovanni Buzzaccarini, Amerigo Vitagliano, Alessandra Andrisani, Carla Mariaflavia Santarsiero, Rossana Cicinelli, Claudia Nardelli, Guido Ambrosini, Ettore Cicinelli

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giovanni BuzzaccariniGynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy. giovanni.buzzaccarini@gmail.com.ORCID http://orcid.org/0000-0002-9466-0178
Amerigo VitaglianoGynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy.
Alessandra AndrisaniGynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy.
Carla Mariaflavia SantarsieroSecond Unit of Obstetrics and Gynecology, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", Piazza G. Cesare 11, Bari, Italy.
Rossana CicinelliSecond Unit of Obstetrics and Gynecology, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", Piazza G. Cesare 11, Bari, Italy.
Claudia NardelliSecond Unit of Obstetrics and Gynecology, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", Piazza G. Cesare 11, Bari, Italy.
Guido AmbrosiniGynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy.
Ettore CicinelliSecond Unit of Obstetrics and Gynecology, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", Piazza G. Cesare 11, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic endometritis (CE) is a frequent hysteroscopic and histological finding which affects embryo transfer implantation during IVF-ICSI cycles. In particular, CE impairs proper decidualization and, subsequently, implantation. Although this correlation has been clearly clarified, a pathophysiological explanation assembling all the studies performed has not been elucidated yet. For this reason, we have structured a systematic review considering all the original articles that evaluated a pathological element involved in CE and implantation impairment.

methodsThe authors searched electronic databases and, after screening, collected 15 original articles. These were fully scanned and used to create a summary pathway.

resultsCE is primarily caused by infections, which lead to a specific cytokine and leukocyte pattern in order to prepare the uterus to fight the noxa. In particular, the immunosuppression requested for a proper semi-allogenic embryo transfer implantation is converted into an immunoreaction, which hampers correct embryo implantation. Moreover, endometrial vascularization is affected and both irregular vessel density and luminal thickening and thrombosis reduce what we have first identified as endometrial flow reserve. Finally, incorrect uterine wave propagation could affect embryo contact with decidua.

conclusionThis is the first summary of evidence on CE pathophysiology and its relationship with infertility. Understanding the CE pathophysiology could improve our knowledge in embryo transfer success.

Indexed as

Embryo ImplantationChronic DiseaseEndometritisFemaleFertilization in VitroHumansInfertility, FemalePregnancyPregnancy RateChronic endometritisEmbryo transferInfertilityIVFPathophysiologyRecurrent pregnancy failuresRecurrent pregnancy loss

Identifiers

PMID33025403
PMCPMC7714873

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.