Evidence map›Paper›PMID 33025399›Full record

ArticleJournal of assisted reproduction and genetics2020

Follicular fluid anti-Müllerian hormone (AMH) concentrations and outcomes of in vitro fertilization cycles with fresh embryo transfer among women at a fertility center.

Caitlin R Sacha, Jorge E Chavarro, Paige L Williams, Jennifer Ford, LiHua Zhang, Patricia K Donahoe, Irene C Souter, Russ Hauser, David Pépin, Lidia Mínguez-Alarcón and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Caitlin R SachaPediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA. csacha@partners.org.ORCID http://orcid.org/0000-0003-2170-1976
Jorge E ChavarroHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Paige L WilliamsHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Jennifer FordHarvard T.H. Chan School of Public Health, Boston, MA, USA.
LiHua ZhangPediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Patricia K DonahoePediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Irene C SouterMGH Fertility Center and Harvard Medical School, Boston, MA, USA.
Russ HauserHarvard T.H. Chan School of Public Health, Boston, MA, USA.
David PépinPediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA. David.pepin@mgh.harvard.edu.
Lidia Mínguez-AlarcónHarvard T.H. Chan School of Public Health, Boston, MA, USA.
EARTH Study Team
Harvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
NIEHS NIH HHS ES009718 and ES000002NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718
6 · The paper itself

Abstract

purposeTo enhance the understanding of the clinical significance of anti-Müllerian hormone (AMH) in follicular fluid, we aimed to determine the variability of AMH concentrations in follicular fluid within and across IVF cycles and whether high follicular fluid AMH concentrations are associated with improved clinical IVF outcomes.

methodsThis was a retrospective cohort study of companion follicular fluid and serum samples from 162 women enrolled in the Environment and Reproductive Health (EARTH) Study between 2010 and 2016. AMH concentrations were quantified using a sandwich enzyme-linked immunosorbent assay. Spearman correlation and intra-class correlation (ICC) were calculated to assess variability of follicular fluid AMH, and generalized linear mixed models were used to evaluate the associations of FF AMH with IVF outcomes.

resultsThe median (interquartile range, IQR) age of the 162 women was 34.0 years (32.0, 37.0). Follicular fluid AMH concentrations were highly correlated between follicles within each IVF cycle (Spearman r = 0.78 to 0.86) and across cycles for each woman (ICC 0.87 (95% CI 0.81 to 0.92)). Compared with women in the highest tertile of FF AMH (mean AMH = 2.3 ng/ml), women in the lowest tertile (mean AMH = 0.2 ng/ml) had lower serum AMH (T1 = 0.1 ng/ml vs. T3 = 0.6 ng/ml, p < 0.0001). In adjusted models, higher tertiles of follicular fluid AMH concentrations were associated with lower mean endometrial thickness and higher probability of clinical pregnancy.

conclusionsFollicular fluid AMH concentrations show little variability between pre-ovulatory follicles, and higher pre-ovulatory follicular fluid AMH may predict a higher probability of clinical pregnancy.

Indexed as

Embryo TransferFertilization in VitroAdultAnti-Mullerian HormoneEstradiolFemaleFollicular FluidHumansOocyte RetrievalOocytesOvarian FolliclePregnancyPregnancy RateProgesteroneRetrospective StudiesAnti-Mullerian HormoneEstradiolProgesteroneFollicular fluidIVF/ICSI outcomeMüllerian inhibiting substance/anti-Müllerian hormonePregnancy

Identifiers

PMID33025399
PMCPMC7642031
OpenAlexW3092588431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.