Evidence map›Paper›PMID 33025325›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson's disease: a systematic review and meta-analysis.

Dan Xie, Qiuyan Shen, Junying Zhou, Yanming Xu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Psychological outcomes of the COVID-19 pandemic in patients with Parkinson's disease: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
    Pooled it
  4. Pooled it
  5. Review
  6. Article
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  15. REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Article
  16. Article
  17. Clinical manifestations and polysomnography-based analysis in nine cases of probable sporadic Creutzfeldt-Jakob disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dan XieDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Qiuyan ShenDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Junying ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. 29736033@qq.com.
Yanming XuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. neuroxym999@163.com.ORCID http://orcid.org/0000-0002-4172-107X
Sichuan University · CN

Funding

the Basic Conditions Platform Construction Project of Sichuan Science and Technology Department 2019JDPT0015the Major Clinical Disease Research Program from the Health and Family planning Commission of Sichuan Province 17ZD011
6 · The paper itself

Abstract

objectiveParkinson's disease (PD) is usually accompanied by rapid eye movement sleep behavior disorder (RBD). A systematic review has concluded that motor manifestations are associated with RBD in PD patients, but whether the same is true of non-motor symptoms is unclear.

methodsA systematic review and meta-analysis was conducted by searching studies related to PD and RBD in PubMed, Web of Science, Embase, and Cochrane databases. Data were pooled where appropriate and used to calculate odds ratios (ORs), mean differences (MDs), or standardized mean differences (SMDs) with 95% confidence intervals (CI). Heterogeneity was assessed using the I

resultsPD patients with RBD were more likely to be male (OR 1.26, 95% CI 1.14-1.40) and older (MD 1.70 years, 95% CI 1.24-2.16) than those of patients without RBD. Patients with RBD were at a higher risk of non-motor symptoms such as constipation (OR 1.94, 95% CI 1.57-2.38), hallucination (OR 2.62, 95% CI 2.01-3.41), depression (SMD 0.39, 95% CI 0.25-0.53), and cognitive impairment (SMD - 0.29, 95% CI - 0.42 to - 0.17) based on standardized questionnaire scores. Similarly, PD patients with RBD suffered more severe motor symptoms and required higher doses of levodopa therapy.

conclusionsThe available evidence suggests that PD patients with RBD suffer severer non-motor and motor symptoms than those without RBD. A potential explanation is that PD patients with RBD present more diffuse neurodegeneration.

Indexed as

Parkinson DiseaseREM Sleep Behavior DisorderFemaleHumansMaleSurveys and QuestionnairesConstipationDepressionNon-motor symptomParkinson’s diseaseRapid eye movement sleep behavior disorder

Identifiers

PMID33025325
OpenAlexW3091876277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.