Evidence map›Paper›PMID 33025234›Full record

SynthesisClinical and experimental nephrology2021

Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular or all-cause mortality in chronic kidney disease: a meta-analysis.

Guangyu Ao, Yushu Wang, Xin Qi, Fengping Wang, Huitao Wen

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangyu Ao *Department of Nephrology, Chengdu First People's Hospital, No.18 North Wanxiang Road, High-tech District, Chengdu, 610016, Sichuan, China.
Yushu Wang *Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
Xin QiDepartment of Neurology, Chengdu Third People's Hospital, Chengdu, Sichuan, China.
Fengping WangDepartment of Nephrology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Huitao WenDepartment of Nephrology, Chengdu First People's Hospital, No.18 North Wanxiang Road, High-tech District, Chengdu, 610016, Sichuan, China. wenhuitao2010@163.com.ORCID http://orcid.org/0000-0003-2805-3924

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is currently controversial whether neutrophil-to-lymphocyte ratio (NLR) has a prognostic role in patients with chronic kidney disease (CKD). We aimed to investigate whether NLR was an independent predictor of cardiovascular or all-cause mortality in CKD patients with or without hemodialysis by performing a meta-analysis.

methodsPubmed, Embase, and Cochrane Library databases are systematically searched for relevant literature that investigated NLR and subsequent cardiovascular or all-cause mortality risk in CKD with or without dialysis. Pooled hazard risk (HR) with 95% confidence interval (CI) was calculated for the high vs. low NLR category.

resultsA total of thirteen studies enrolling 116,709 patients were identified and analyzed. In summary, high NLR was associated with an increased risk of all-cause mortality (HR 1.93, 95% CI 1.87-2.00; P < 0.00001) and cardiovascular mortality (HR 1.45, 95% CI 1.18-1.79, P < 0.001). Subgroup analysis indicated that high NLR are independently associated with all-cause mortality risk in dialysis patients (HR 1.94, 95% CI 1.87-2.01; P < 0.00001).

conclusionsThis meta-analysis indicates a high NLR is related to all-cause mortality and cardiovascular mortality in patients with chronic kidney disease. Dialysis patients with high NLR are candidates at high risk of mortality to allow for earlier interventions. Further large scale and more rigorously designed studies are warranted to confirm the prognostic value of NLR in the different stages of CKD.

Indexed as

LymphocytesNeutrophilsCardiovascular DiseasesCause of DeathHumansPrognosisRenal Insufficiency, ChronicRiskCardiovascular mortalityChronic kidney diseaseMeta-analysisMortalityNeutrophil-to-lymphocyte ratio

Identifiers

PMID33025234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.