Evidence map›Paper›PMID 33025104›Full record

Trial reportInternational journal of colorectal disease2021

Non-Doppler hemorrhoidal artery ligation and hemorrhoidopexy combined with pudendal nerve block for the treatment of hemorrhoidal disease: a non-inferiority randomized controlled trial.

Konstantinos Perivoliotis, Michail Spyridakis, Elias Zintzaras, Eleni Arnaoutoglou, Manousos-Georgios Pramateftakis, Konstantinos Tepetes

Registry-linked trialAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03298997 (Comparison Between the Ligation and Hemorrhoidopexy Technique and the Conventional Ligation of Hemorrhoidal Arteries Using Ultrasound), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03298997 nacompletednot on this map

Comparison Between the Ligation and Hemorrhoidopexy Technique and the Conventional Ligation of Hemorrhoidal Arteries Using Ultrasound: a Prospective, Randomized Controlled Study

TypeinterventionalSponsorLarissa University HospitalRan2017 to 2020Enrolled60ConditionsHemorrhoidsArmsLigation and Hemorrhoidopexy, Ultrasound Guided Ligation of Hemorrhoidal Arteries
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Haemorrhoidal artery ligation: Is Doppler guidance useful? A systematic review and meta-analysis of randomized controlled trials.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Konstantinos PerivoliotisDepartment of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece. kperi19@gmail.com.ORCID https://orcid.org/0000-0002-6622-5734
Michail SpyridakisDepartment of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.ORCID https://orcid.org/0000-0002-7093-1332
Elias ZintzarasDepartment of Biomathematics, School of Medicine, University of Thessaly, Larissa, Greece.ORCID https://orcid.org/0000-0002-4450-0125
Eleni ArnaoutoglouDepartment of Anesthesiology, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.ORCID https://orcid.org/0000-0003-0441-9442
Manousos-Georgios PramateftakisFourth Surgical Department, Medical School, Aristotle University of Thessaloniki, 57010, Thessaloniki, Greece.
Konstantinos TepetesDepartment of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.ORCID https://orcid.org/0000-0001-9435-6849
University Hospital of Larissa · GRAristotle University of Thessaloniki · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we proposed a combined outpatient treatment modality for hemorrhoidal disease.

methodsThis study was a prospective non-inferiority randomized controlled trial (RCT). The experimental group included the dearterialization and hemorrhoidopexy under pudendal nerve block, whereas the comparator consisted of the standard Doppler guided hemorrhoidal artery ligation and hemorrhoidopexy, under spinal anesthesia. As primary hypothesis, we considered the non-inferiority of the proposed modality in terms of the presenting symptom remission rate (non-inferiority margin: 10%). Randomization was based on a 1:1 ratio. Blinding was confined to the patient and the investigator.

resultsOverall, 60 patients were enrolled. The primary hypothesis of this RCT (96.7% vs 73.3%) was validated. The experimental group was associated with a lower operation duration and an expedited onset of mobilization and feeding. Moreover, a favorable profile regarding short-term morbidity and analgesia was identified. The control group displayed a higher pile recurrence rate and a suboptimal patient satisfaction. A significant effect of the treatment modality in most of the SF-36 components was confirmed.

conclusionsThe proposed treatment modality was associated with favorable short and long-term outcomes. Due to specific limitations, further RCTs, with a larger sample size, are required. Trial Registration ClinicalTrials.gov : NCT03298997.

Indexed as

HemorrhoidectomyHemorrhoidsPudendal NerveArteriesHumansLigationTreatment OutcomeHemorrhoidopexyHemorrhoidsLigationUltrasound; pudendal

Identifiers

PMID33025104
OpenAlexW3092419201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.