Evidence map›Paper›PMID 33024981›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State.

Nicola F Müller, Cassia Wagner, Chris D Frazar, Pavitra Roychoudhury, Jover Lee, Louise H Moncla, Benjamin Pelle, Matthew Richardson, Erica Ryke, Hong Xie and 33 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

Nicola F MüllerFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Cassia WagnerFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chris D FrazarUniversity of Washington, Seattle, WA, USA.
Pavitra RoychoudhuryFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jover LeeFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Louise H MonclaFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Benjamin PelleUniversity of Washington, Seattle, WA, USA.
Matthew RichardsonUniversity of Washington, Seattle, WA, USA.
Erica RykeUniversity of Washington, Seattle, WA, USA.
Hong XieUniversity of Washington, Seattle, WA, USA.
Lasata ShresthaUniversity of Washington, Seattle, WA, USA.
Amin AddetiaUniversity of Washington, Seattle, WA, USA.
Victoria M RachleffFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nicole A P LiebermanUniversity of Washington, Seattle, WA, USA.
Meei-Li HuangUniversity of Washington, Seattle, WA, USA.
Romesh GautomWashington State Department of Health, Shoreline, WA, USA.
Geoff MellyWashington State Department of Health, Shoreline, WA, USA.
Brian HiattWashington State Department of Health, Shoreline, WA, USA.
Philip DykemaWashington State Department of Health, Shoreline, WA, USA.
Amanda AdlerSeattle Children's Research Institute, Seattle, WA, USA.
Elisabeth BrandstetterUniversity of Washington, Seattle, WA, USA.
Peter D HanUniversity of Washington, Seattle, WA, USA.
Kairsten FayFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Misja LlcisinFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kristen LacombeSeattle Children's Research Institute, Seattle, WA, USA.
Thomas R SibleyFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Melissa TruongUniversity of Washington, Seattle, WA, USA.
Caitlin R WolfUniversity of Washington, Seattle, WA, USA.
Michael BoeckhFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Janet A EnglundUniversity of Washington, Seattle, WA, USA.
Michael FamulareInstitute for Disease Modeling, Bellevue, WA, USA.
Barry R LutzUniversity of Washington, Seattle, WA, USA.
Mark J RiederBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.
Matthew ThompsonUniversity of Washington, Seattle, WA, USA.
Jeffrey S DuchinUniversity of Washington, Seattle, WA, USA.
Lea M StaritaUniversity of Washington, Seattle, WA, USA.
Helen Y ChuUniversity of Washington, Seattle, WA, USA.
Jay ShendureUniversity of Washington, Seattle, WA, USA.
Keith R JeromeFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Scott LindquistWashington State Department of Health, Shoreline, WA, USA.
Alexander L GreningerFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Deborah A NickersonUniversity of Washington, Seattle, WA, USA.
Trevor BedfordFred Hutchinson Cancer Research Center, Seattle, WA, USA.

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
Real-time tracking of virus evolution for vaccine strain selection and epidemiological investigationR35GM119774 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2016 to 2025
$4.1M
NIGMS NIH HHS R35 GM119774NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

The rapid spread of SARS-CoV-2 has gravely impacted societies around the world. Outbreaks in different parts of the globe are shaped by repeated introductions of new lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2 viral genomes from Washington State to characterize how the spread of SARS-CoV-2 in Washington State (USA) was shaped by differences in timing of mitigation strategies across counties, as well as by repeated introductions of viral lineages into the state. Additionally, we show that the increase in frequency of a potentially more transmissible viral variant (614G) over time can potentially be explained by regional mobility differences and multiple introductions of 614G, but not the other variant (614D) into the state. At an individual level, we see evidence of higher viral loads in patients infected with the 614G variant. However, using clinical records data, we do not find any evidence that the 614G variant impacts clinical severity or patient outcomes. Overall, this suggests that at least to date, the behavior of individuals has been more important in shaping the course of the pandemic than changes in the virus.

Identifiers

PMID33024981
PMCPMC7536883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.