Evidence map›Paper›PMID 33024972›Full record

ArticlebioRxiv : the preprint server for biology2020

Hallmarks of

Boris Krichel, Ganesh Bylapudi, Christina Schmidt, Clement Blanchet, Robin Schubert, Lea Brings, Martin Koehler, Renato Zenobi, Dmitri Svergun, Kristina Lorenzen and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Boris KrichelHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Ganesh BylapudiInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
Christina SchmidtEuropean XFEL GmbH, Schenefeld, Germany.
Clement BlanchetEMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany.
Robin SchubertEuropean XFEL GmbH, Schenefeld, Germany.
Lea BringsEuropean XFEL GmbH, Schenefeld, Germany.
Martin KoehlerETH Zurich D-CHAB Lab of Organic Chemistry, Zürich, Switzerland.
Renato ZenobiETH Zurich D-CHAB Lab of Organic Chemistry, Zürich, Switzerland.
Dmitri SvergunEMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany.
Kristina LorenzenEuropean XFEL GmbH, Schenefeld, Germany.
Ramakanth MadhugiriInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.
Charlotte UetrechtHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronaviruses infect many different species including humans. The last two decades have seen three zoonotic coronaviruses with SARS-CoV-2 causing a pandemic in 2020. Coronaviral non-structural proteins (nsp) built up the replication-transcription complex (RTC). Nsp7 and nsp8 interact with and regulate the RNA-dependent RNA-polymerase and other enzymes in the RTC. However, the structural plasticity of nsp7+8 complex has been under debate. Here, we present the framework of nsp7+8 complex stoichiometry and topology based on a native mass spectrometry and complementary biophysical techniques of nsp7+8 complexes from seven coronaviruses in the genera

Identifiers

PMID33024972
PMCPMC7536876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.