ArticleAnimal models and experimental medicine2020
A 30% incidence of renal cysts with varying sizes and densities in biomedical research swine is not associated with renal dysfunction.
Article in Animal models and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- A case of hydronephrosis due to intrarenal ureteral obstruction in a Japanese Black calf.The Journal of veterinary medical science · 2024Article
- Influence of a simple cyst on kidney function.Frontiers in medicine · 2024Article
- Spontaneous Polycystic Kidneys with Chronic Renal Failure in an Aged House Musk Shrew (Veterinary sciences · 2022Article
- A 30% incidence of renal cysts with varying sizes and densities in biomedical research swine is not associated with renal dysfunction.Animal models and experimental medicine · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal cystic disease arising from various etiologies results in fluid-filled cavities within the kidneys. Moreover, preexisting renal dysfunction has been shown to exacerbate multiple pathologies. While swine bred for biomedical research are often clinically inspected for illness/parasites, more advanced diagnostics may aid in uncovering underlying renal abnormalities.
methodsComputed tomography was performed in 54 female prepubertal Yorkshire swine to characterize renal cysts; urine and blood chemistry, and histology of cysts were also performed.
resultsDigital reconstruction of right and left kidneys demonstrated that roughly one-third of the animals (17/54; 31%) had one or more renal cyst. Circulating biomarkers of renal function were not different between animals that had cysts and those that did not. Alternatively, urinary glucose (
conclusionThis study provides valuable insight for future studies focusing on kidney function in swine bred for biomedical research.
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