Evidence map›Paper›PMID 33024925›Full record

ArticleCurrent developments in nutrition2020

Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial.

Beverly Dosso, Charlotte Mae K Waits, Kelli N Simms, Susan Sergeant, D Clark Files, Timothy D Howard, Carl D Langefeld, Floyd H Chilton, Elaheh Rahbar

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00609180 (Prospective, Randomized, Multi-Center Trial of Initial Trophic Enteral Feeding Followed by Advancement to Full-Calorie Enteral Feeding vs. Early Advancement to Full-Calorie Enteral Feeding in Patients With Acute Lung Injury), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00609180 phase3terminatednot on this map

Prospective, Randomized, Multi-Center Trial of Initial Trophic Enteral Feeding Followed by Advancement to Full-Calorie Enteral Feeding vs. Early Advancement to Full-Calorie Enteral Feeding in Patients With Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS) and Prospective, Randomized, Blinded, Placebo-Controlled, Multi-Center Trial of Omega-3 Fatty Acid, Gamma-Linolenic Acid, and Anti-Oxidant Supplementation in the Management of Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2007 to 2009Enrolled272ConditionsRespiratory Distress Syndrome, AdultArmsMinimal (Trophic) Feeding, Full Feeding, Omega-3 Fatty Acids and Antioxidant Supplements, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Fatty acid desaturase genetic variations in heart failure and cardiovascular disease.American heart journal plus : cardiology research and practice · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Beverly DossoDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-0401-8964
Charlotte Mae K WaitsDepartment of Biomedical Engineering, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Winston-Salem, NC, USA.
Kelli N SimmsDepartment of Biomedical Engineering, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Winston-Salem, NC, USA.
Susan SergeantDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
D Clark FilesDepartment of Internal Medicine, Sections in Pulmonary and Critical Care Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Timothy D HowardDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Carl D LangefeldCenter for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Floyd H ChiltonDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, USA.
Elaheh RahbarDepartment of Biomedical Engineering, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Winston-Salem, NC, USA.ORCID 0000-0001-5941-7917
Wake Forest University · USVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · USUniversity of Arizona · US

Funding

Role of PUFA-Gene Interactions in Health DisparitiesR01AT008621 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FLOYD H CHILTON, Susan Schembre · 2016 to 2026
$5.4M
An Integrated Investigation of the Interaction Between PUFAs and Genetic Variants in Trauma and Critical CareK25HL133611 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAHBAR, ELAHEH · 2017 to 2021
$841k
NCCIH NIH HHS R01 AT008621NHLBI NIH HHS K25 HL133611
6 · The paper itself

Abstract

backgroundNutrition in the intensive care unit is vital for patient care; however, immunomodulatory diets rich in PUFAs like γ-linolenic acid (GLA), EPA, and DHA remain controversial for patients with acute respiratory distress syndrome. We postulate that genetic variants impacting PUFA metabolism contribute to mixed responses to PUFA-rich diets.

objectivesIn this study, we aimed to test the effects of single nucleotide polymorphism (SNP) rs174537 on differential responses to PUFA-rich diets.

methodsWe performed a secondary analysis of the OMEGA trial (NCT00609180) where 129 subjects received placebo control diets and 143 received omega-oil. DNA was extracted from buffy coats and used to genotype rs174537; plasma was used to quantitate PUFAs. We tested for SNP-diet interactions on PUFA concentrations, inflammatory biomarkers, and patient outcomes.

resultsWe observed that all individuals receiving omega-oil displayed significantly higher concentrations of GLA, EPA, and DHA (all

conclusionsThis study highlights the importance of genetic and racial contributions to PUFA metabolism and inflammation. In particular, rs174537 had a significant impact on circulating DHA and urinary isoprostane concentrations. Given our relatively small sample size, further investigations in larger multiethnic cohorts are needed to evaluate the impact of rs174537 on fatty acid metabolism and downstream inflammation.

Indexed as

ARDSDHAEPAFADSGLAomega-3OMEGA trialPUFArs174537SNP–diet interactions

Identifiers

PMID33024925
PMCPMC7524639
OpenAlexW3086596983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.