Evidence map›Paper›PMID 33024879›Full record

ArticleIBRO reports2020

The effect of levomepromazine on the healthy and injured developing mouse brain - An

Anna Posod, Ira Winkler, Karina Wegleiter, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna PosodPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Ira WinklerPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Karina WegleiterPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Eva HuberPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Martina UrbanekPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Ursula Kiechl-KohlendorferPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Elke GriesmaierPediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levomepromazine (LMP) is a phenothiazine neuroleptic drug with strong analgesic and sedative properties that is increasingly used off-label in pediatrics and is being discussed as an adjunct therapy in neonatal intensive care. Basic research points towards neuroprotective potential of phenothiazines, but LMP's effect on the developing brain is currently unknown. The aim of the present study was to assess LMP as a pharmacologic strategy in established neonatal

Indexed as

bw, body weightCCK-8, Cell Counting Kit-8CD-1 mouseHT-22i.c., intracraniali.p., intraperitonealIQR, interquartile rangeLevomepromazineLMP, levomepromazineMethotrimeprazineNaCl, sodium chlorideNeonatal excitotoxic brain injuryNICU, Neonatal Intensive Care UnitPBS, phosphate-buffered salinePhenothiazinePx, postnatal day xTUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling

Identifiers

PMID33024879
PMCPMC7527626
OpenAlexW3088898510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.