Evidence map›Paper›PMID 33024815›Full record

ArticleMolecular therapy oncolytics2020

Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor.

Rui Han, Olivia Nusbaum, Xinyi Chen, Yong Zhu

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 71 citations in OpenAlex.

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  16. Next-Cell Hypothesis: Mechanism of Obesity-Associated Carcinogenesis.Advances in experimental medicine and biology · 2024
    Review
  17. Article
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  20. Epigenetic effects of herbal medicine.Clinical epigenetics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rui HanSchool of Public Health, Yale University, New Haven, CT 06520, USA.
Olivia NusbaumSchool of Public Health, Yale University, New Haven, CT 06520, USA.
Xinyi ChenDepartment of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, P. R. China.
Yong ZhuSchool of Public Health, Yale University, New Haven, CT 06520, USA.
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CNYale University · US

Funding

Explore piRNA as a novel therapeutics for hepatocellular carcinomaR21CA238100 · NCI · YALE UNIVERSITY · PI ZHU, YONG · 2019 to 2020
$401k
NCI NIH HHS R21 CA238100
6 · The paper itself

Abstract

Liver cancer is the fastest growing cause of cancer deaths in the United States due to its aggressiveness and lack of effective therapies. The current preclinical study examines valeric acid (pentanoic acid [C

Indexed as

3D formationapoptosiscell migrationcell proliferationcolony formationHDACihepatocellular carcinomalipid nanoparticlemouse modelvaleric acid

Identifiers

PMID33024815
PMCPMC7520432
OpenAlexW3081610886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.