Evidence map›Paper›PMID 33024737›Full record

ArticleJournal of lipid and atherosclerosis2020

Mesenchymal Stem Cell-Mediated Therapy of Peripheral Artery Disease Is Stimulated by a Lamin A-Progerin Binding Inhibitor.

Soon Chul Heo, Yang Woo Kwon, Gyu Tae Park, Sang Mo Kwon, Sun Sik Bae, Bum-Joon Park, Jae Ho Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid and atherosclerosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Soon Chul HeoDepartment of Oral Physiology and Periodontal Diseases Signaling Network Research Center, School of Dentistry, Pusan National University College of Medicine, Yangsan, Korea.
Yang Woo KwonDepartment of Physiology, Pusan National University College of Medicine, Yangsan, Korea.
Gyu Tae ParkDepartment of Physiology, Pusan National University College of Medicine, Yangsan, Korea.
Sang Mo KwonDepartment of Physiology, Pusan National University College of Medicine, Yangsan, Korea.ORCID https://orcid.org/0000-0001-5951-2877
Sun Sik BaeDepartment of Pharmacology, Pusan National University College of Medicine, Yangsan, Korea.ORCID https://orcid.org/0000-0002-1027-6639
Bum-Joon ParkDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan, Korea.
Jae Ho KimDepartment of Physiology, Pusan National University College of Medicine, Yangsan, Korea.ORCID https://orcid.org/0000-0003-4323-4790
Pusan National University · KRPusan National University Yangsan Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHuman adipose tissue-derived mesenchymal stem cells (ASCs) have been reported to promote angiogenesis and tissue repair. However, poor survival and engraftment efficiency of transplanted ASCs are the major bottlenecks for therapeutic application. The present study aims to improve the therapeutic efficacy of ASCs for peripheral artery diseases.

methodsHydrogen peroxide (H

resultsWe identified that the inhibitor of lamin A-progerin binding, JH4, protects ASCs against H

conclusionJH4 exerts anti-apoptotic effects in ASCs in conditions of oxidative stress, and contributes to the repair of ischemic hind limb injury by improving cell survival.

Indexed as

ApoptosisMesenchymal stem cellsOxidative stressPeripheral artery disease

Identifiers

PMID33024737
PMCPMC7521968
OpenAlexW3087355286

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.