Evidence map›Paper›PMID 33024582›Full record

ArticleJournal of gastric cancer2020

Postprandial Changes in Gastrointestinal Hormones and Hemodynamics after Gastrectomy in Terms of Early Dumping Syndrome.

Jun-Young Yang, Hyuk-Joon Lee, Fadhel Alzahrani, Seung Joon Choi, Woon Kee Lee, Seong-Ho Kong, Do-Joong Park, Han-Kwang Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jun-Young YangDepartment of Surgery, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0003-4789-7655
Hyuk-Joon LeeDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-9530-647X
Fadhel AlzahraniDepartment of Surgery, King Faisal Hospital, Makkah, Saudi Arabia.
Seung Joon ChoiDepartment of Radiology, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0003-3861-7682
Woon Kee LeeDepartment of Surgery, Gachon University Gil Medical Center, Incheon, Korea.
Seong-Ho KongDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-3929-796X
Do-Joong ParkDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-9644-6127
Han-Kwang YangDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-3495-3048
Gachon University Gil Medical Center · KRSeoul National University · KRSeoul National University Hospital · KRKing Faisal Specialist Hospital & Research Centre · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to examine the early postprandial changes in gastrointestinal (GI) hormones and hemodynamics in terms of early dumping syndrome after gastrectomy for gastric cancer. MATERIALS AND

methodsForty patients who underwent gastrectomy for gastric cancer and 18 controls without previous abdominal surgery were enrolled. Before and 20 minutes after liquid meal ingestion, blood glucose, glucagon-like peptide-1 (GLP-1), and GLP-2 concentrations and superior mesenteric artery (SMA) and renal blood flow were measured. The patients' heart rates were recorded at 5-minute intervals. All subjects were examined for dumping syndrome using a questionnaire based on Sigstad's clinical diagnostic index.

resultsThe postprandial increases in blood glucose, GLP-1, and GLP-2 levels as well as SMA blood flow and heart rate were greater in patients who underwent gastrectomy than in controls (all P<0.010). Patients who underwent gastrectomy showed a significantly decreased renal blood flow (P<0.001). Among patients who underwent gastrectomy, distal gastrectomy was a significant clinical factor associated with a lower risk of early dumping syndrome than total gastrectomy (hazard ratio, 0.092; 95% confidence interval, 0.013-0.649; P=0.017). Patients who underwent total gastrectomy showed a greater postprandial increase in blood glucose (P<0.001), GLP-1 (P=0.030), and GLP-2 (P=0.002) levels as well as and heart rate (P=0.013) compared to those who underwent distal gastrectomy.

conclusionsEarly postprandial changes in GI hormones and hemodynamics were greater in patients who underwent gastrectomy than in controls, especially after total gastrectomy, suggesting that these changes play a crucial role in the pathophysiology of early dumping syndrome.

Indexed as

Dumping syndromeGastrectomyGastrointestinal hormonesGlucoseSplanchnic circulation

Identifiers

PMID33024582
PMCPMC7521986
OpenAlexW3048570820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.