Evidence map›Paper›PMID 33024460›Full record

ReviewJournal of arrhythmia2020

Cardiac arrhythmias in patients with COVID-19.

Yueying Wang, Zhaojia Wang, Gary Tse, Lin Zhang, Elaine Y Wan, Yutao Guo, Gregory Y H Lip, Guangping Li, Zhibing Lu, Tong Liu

Abstract readReview
In one paragraph

Review in Journal of arrhythmia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. COVID-19-associated Brugada pattern electrocardiogram: Systematic review of case reports.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Pooled it
  2. Pooled it
  3. Observational
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  13. COVID-19 and Atrial Fibrillation: Predicting to Prevent.Arquivos brasileiros de cardiologia · 2024
    Article
  14. The Potential Mechanisms of Arrhythmia in Coronavirus disease-2019.International journal of medical sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yueying WangTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China.
Zhaojia WangTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China.
Gary TseTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China.ORCID https://orcid.org/0000-0001-5510-1253
Lin ZhangDepartment of Cardiology Zhongnan Hospital of Wuhan University Wuhan People's Republic of China.
Elaine Y WanDivision of Cardiology Department of Medicine Vagelos College of Physicians and Surgeons Columbia University New York NY USA.
Yutao GuoMedical School of Chinese PLA Department of Cardiology Chinese PLA General Hospital Beijing China.
Gregory Y H LipMedical School of Chinese PLA Department of Cardiology Chinese PLA General Hospital Beijing China.ORCID https://orcid.org/0000-0002-7566-1626
Guangping LiTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China.
Zhibing LuDepartment of Cardiology Zhongnan Hospital of Wuhan University Wuhan People's Republic of China.
Tong LiuTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China.ORCID https://orcid.org/0000-0003-0482-0738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major global public health concern. Although SARS-CoV-2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. Cardiac arrhythmias are often observed in patients with COVID-19, especially in severe cases, and more likely contribute to the high risk of adverse outcomes. Arrhythmias should be regarded as one of the main complications of COVID-19. Mechanistically, a number of ion channels can be adversely affected in COVID-19, leading to alterations in cardiac conduction and/or repolarization properties, as well as calcium handling, which can predispose to cardiac arrhythmogenesis. In addition, several antimicrobials that are currently used as potential therapeutic agents for COVID-19, such as chloroquine, hydroxychloroquine and azithromycin, have uncertain benefit, and yet may induce electrocardiographic QT prolongation with potential ventricular pro-arrhythmic effects. Continuous electrocardiogram monitoring, accurate and prompt recognition of arrhythmias are important. The present review focuses on cardiac arrhythmias in patients with COVID-19, its underlying mechanisms, and proposed preventive and therapeutic strategies.

Indexed as

angiotensin‐converting enzyme‐2arrhythmiaCOVID‐19electrocardiogramQT intervalSARS‐CoV‐2

Identifiers

PMID33024460
PMCPMC7532267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.