SynthesisNature reviews. Rheumatology2020
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.
Synthesis in Nature reviews. Rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 400 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Pain Neuroscience Education and Strength Training Program in Patients With Fibromyalgia
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation on Pain and Quality of Life in Patients With Fibromyalgia: a Single-blind, Randomized Controlled Trial
Effects of Indoor Activity on the Integrity and Function of the Intestinal Barrier of Patients With Fibromyalgia and Irritable Bowel Syndrome
ObServational StUdy of CaNnabis ExtRact in FIbromyalgia SyndromE
Use of Transcranial Direct Current Stimulation (TDCS) in an Active Pain Coping Program for Patients With Fibromyalgia: A Randomized Control Trial.
High-Intensity Interval Training (HIIT) and Transcranial Direct Current Stimulation (tDCS) in Women With Fibromyalgia - Effects on Clinical and Neuro-physiological Variables: Randomized Clinical Trial Protocol
Effects of a Foot Core Training Program on Foot Pain, Function, and Pressure Pain Sensitivity in Patients With Fibromyalgia: A Quasi-Experimental Study.
Impact of Different Dietary Strategies in the Management of Overweight and Obesity in Patients With Fibromyalgia: Effects on Pain, Disease Severity, Nutritional and Metabolic Profile, Gut Microbiota and Microbial Metabolites, and Brain GABA and Glutamate Levels
Evaluation of the Effect of Curcumin and Piperine Supplementation on Clinical Outcome in Fibromyalgia Patients.
Who cites it
400 citing papers in PubMed, 15 syntheses or guidelines pooled it, 730 citations in OpenAlex.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- SIMFER guidelines on physical modalities for chronic primary pain management.European journal of physical and rehabilitation medicine · 2026Guideline
- Perception and lived experience of movement in patients with fibromyalgia: a qualitative systematic review with meta-synthesis and meta-summary.Clinical rheumatology · 2026Pooled it
- Comparison of clinical efficacy of different acupuncture methods in the treatment of fibromyalgia: a network meta-analysis based on randomized controlled trials.Frontiers in neurology · 2026Pooled it
- Pain in People With Fibromyalgia Syndrome (FMS) Undergoing or Following Surgery: A Systematic Narrative Review.Pain research & management · 2026Pooled it
- Fibromyalgia in cancer patients: a systematic review and clinical implications for integrated care.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Efficacy and safety of TNX-102 SL in patients with fibromyalgia: a systematic review and meta-analysis.Pain management · 2025Pooled it
- Breast Implant Illness: Symptoms, Outcomes with Explantation and Potential Etiologies-A Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2025Pooled it
- Treatments for enhancing sleep quality in fibromyalgia: a systematic review and meta-analysis.Rheumatology (Oxford, England) · 2025Pooled it
- Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in China.Journal of evidence-based medicine · 2025Guideline
- Pooled it
- Optimal aerobic exercise dose for pain relief in fibromyalgia syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- The efficacy of acupuncture treatment for fibromyalgia syndrome: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The effectiveness of stretching exercises in patients with fibromyalgia: A systematic review.Clinical rheumatology · 2024Pooled it
- Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).European journal of pain (London, England) · 2026Trial
- The effects of EXOPULSE Mollii Suit in patients with fibromyalgia: a double-blind randomized sham-controlled trial (EXOFIB2).Pain medicine (Malden, Mass.) · 2026Trial
- Trial
- Transcutaneous Electrical Nerve Stimulation and Pain With Movement in People With Fibromyalgia: A Cluster Randomized Clinical Trial.JAMA network open · 2026Trial
- Efficacy and mechanism of supervised adapted physical activity on quality of life for patients with fibromyalgia: single-center, prospective, randomised clinical and neuroimaging study.Scientific reports · 2026Trial
340 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia is characterized by chronic widespread pain, fatigue, sleep disturbances and functional symptoms. The etiopathogenesis, diagnostic criteria and classification criteria of fibromyalgia are still debated and, consequently, so are the strategies for treating this condition. Fibromyalgia is the third most frequent musculoskeletal condition, and its prevalence increases with age. However, although diagnosis has improved with the evolution of more accurate diagnostic criteria, a considerable proportion of physicians still fail to recognize the syndrome. Many factors contribute to the development of fibromyalgia in a unique manner: genetic predisposition, personal experiences, emotional-cognitive factors, the mind-body relationship and a biopsychological ability to cope with stress. The multiple components of the pathogenesis and maintenance of the condition necessitate a multi-modal treatment approach. Individually tailored treatment is an important consideration, with the increasing recognition that different fibromyalgia subgroups exist with different clinical characteristics. Consequently, although an evidence-based approach to fibromyalgia management is always desirable, the approach of physicians is inevitably empirical, and must have the aim of creating a strong alliance with the patient and formulating shared, realistic treatment goals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.