Evidence map›Paper›PMID 33024106›Full record

ArticleNature communications2020

Millisecond dynamics of an unlabeled amino acid transporter.

Tina R Matin, George R Heath, Gerard H M Huysmans, Olga Boudker, Simon Scheuring

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
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  4. HS-AFM Applications to Study Membrane Proteins.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
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  7. Conformational free energy landscape of a glutamate transporter and microscopic details of its transport mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  11. Article
  12. Review
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  17. Review
  18. Visualizing Intramolecular Dynamics of Membrane Proteins.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tina R Matin *Department of Anesthesiology, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA.
George R Heath *Department of Anesthesiology, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0001-6431-2191
Gerard H M HuysmansDepartment of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-4156-8252
Olga BoudkerDepartment of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA.
Simon ScheuringDepartment of Anesthesiology, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA. sis2019@med.cornell.edu.ORCID http://orcid.org/0000-0003-3534-069X
Cornell University · USHoward Hughes Medical Institute · US

Funding

High-speed atomic force microscopy with microsecond time resolution for the study of channels and transportersR01NS110790 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Simon Scheuring · 2019 to 2026
$2.4M
Howard Hughes Medical InstituteNINDS NIH HHS R01 NS110790
6 · The paper itself

Abstract

Excitatory amino acid transporters (EAATs) are important in many physiological processes and crucial for the removal of excitatory amino acids from the synaptic cleft. Here, we develop and apply high-speed atomic force microscopy line-scanning (HS-AFM-LS) combined with automated state assignment and transition analysis for the determination of transport dynamics of unlabeled membrane-reconstituted Glt

Indexed as

Amino Acid Transport SystemsArchaeal ProteinsImage Processing, Computer-AssistedMicroscopy, Atomic ForceProtein SubunitsSignal-To-Noise RatioAmino Acid Transport SystemsArchaeal ProteinsProtein Subunits

Identifiers

PMID33024106
PMCPMC7538599
OpenAlexW3092363316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.