Evidence map›Paper›PMID 33024041›Full record

ArticlemBio2020

Copy Number of an Integron-Encoded Antibiotic Resistance Locus Regulates a Virulence and Opacity Switch in Acinetobacter baumannii AB5075.

Sarah E Anderson, Chui Yoke Chin, David S Weiss, Philip N Rather

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Modular, inducible, and titratable expression systems forbioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Direct prediction of antimicrobial resistance inFrontiers in microbiology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah E AndersonDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
Chui Yoke ChinDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
David S WeissDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-0980-7866
Philip N RatherDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA prather@emory.edu.
Emory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Antimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7M
Mechanisms of phenotypic antibiotic resistance in Gram-negative bacteriaR01AI141883 · NIAID · EMORY UNIVERSITY · PI WEISS, DAVID S · 2018 to 2022
$2.2M
Phase variable control of Acinetobacter baumannii virulenceR21AI115183 · NIAID · EMORY UNIVERSITY · PI RATHER, PHILIP N. · 2015 to 2016
$350k
Regulation of a virulence switch in Acinetobacter baumanniiR21AI142489 · NIAID · EMORY UNIVERSITY · PI RATHER, PHILIP N. · 2019 to 2020
$349k
BLRD Research Career Scientist Award ApplicationIK6BX004470 · VA · VETERANS HEALTH ADMINISTRATION · PI Philip N. Rather · 2019 to 2026
–
Manipulating a Virulence Switch to Combat Acinetobacter baumannii InfectionsI01BX001725 · VA · VETERANS HEALTH ADMINISTRATION · PI RATHER, PHILIP N. · 2013 to 2024
–
Molecular mechanisms of antibiotic resistance in Acinetobacter baumanniiI01BX002788 · VA · VETERANS HEALTH ADMINISTRATION · PI WEISS, DAVID S · 2016 to 2019
–
BLRD VA I01 BX001725BLRD VA I01 BX002788BLRD VA IK6 BX004470NIAID NIH HHS R01 AI141883NIAID NIH HHS R21 AI115183NIAID NIH HHS R21 AI142489NIAID NIH HHS T32 AI106699NIH HHS P51 OD011132
6 · The paper itself

Abstract

We describe a novel genetic mechanism in which tandem amplification of a plasmid-borne integron regulates virulence, opacity variation, and global gene expression by altering levels of a putative small RNA (sRNA) in

Indexed as

Gene DosageGene Expression Regulation, BacterialIntegronsAcinetobacter baumanniiAnimalsAnti-Bacterial AgentsDrug Resistance, BacterialFemaleMiceMice, Inbred C57BLPhenotypeVirulenceAnti-Bacterial AgentsAcinetobacterintegronphenotypic switchingsRNAvirulence regulation

Identifiers

PMID33024041
PMCPMC7542366
OpenAlexW3092579029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.