Evidence map›Paper›PMID 33024038›Full record

ArticlemBio2020

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple

M Florencia Haurat, Nichollas E Scott, Gisela Di Venanzio, Juvenal Lopez, Benjamin Pluvinage, Alisdair B Boraston, Michael J Ferracane, Mario F Feldman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Mucinase fromFrontiers in microbiology · 2026
    Article
  6. Article
  7. High Prevalence of Virulence andPathogens (Basel, Switzerland) · 2025
    Article
  8. Circulation research · 2025
    Article
  9. Article
  10. Analysis Strategy for Identifying theMolecules (Basel, Switzerland) · 2025
    Article
  11. Article
  12. UnravelingAnalytical chemistry · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

M Florencia HauratDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Nichollas E ScottDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Gisela Di VenanzioDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Juvenal LopezDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Benjamin PluvinageDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
Alisdair B BorastonDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
Michael J FerracaneDepartment of Chemistry, University of Redlands, Redlands, California, USA.
Mario F FeldmanDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA mariofeldman@wustl.edu.
Washington University in St. Louis · USUniversity of Victoria · CAPeter Doherty Institute · AUUniversity of Redlands · US

Funding

Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
Molecular Insights into the Uropathogenesis of MDR Acinetobacter baumanniiR01AI144120 · NIAID · WASHINGTON UNIVERSITY · PI Mario Feldman · 2019 to 2026
$4.1M
Protein-Glycan Interaction Resource of the CFGR24GM098791 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D, PAULSON, JAMES C · 2011 to 2013
$2.6M
CIHR PJT 159786NIAID NIH HHS R01 AI144120NIGMS NIH HHS P41 GM103694NIGMS NIH HHS R24 GM098791
6 · The paper itself

Abstract

Glycans decorate proteins and affect their biological function, including protection against proteolytic degradation. However, pathogenic, and commensal bacteria have evolved specific glycoproteases that overcome the steric impediment posed by carbohydrates, cleaving glycoproteins precisely at their glycosylation site(s). Medically relevant

Indexed as

Host Microbial InteractionsAcinetobacterAcinetobacter InfectionsBacterial ProteinsGlycoproteinsHumansPeptide HydrolasesProteolysisType II Secretion SystemsVirulence FactorsBacterial ProteinsGlycoproteinsPeptide HydrolasesType II Secretion SystemsVirulence FactorsAcinetobacterCpaAglycobiologyglycoproteaseT2SS

Identifiers

PMID33024038
PMCPMC7542363
OpenAlexW3092199848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.