Evidence map›Paper›PMID 33024031›Full record

ArticlemBio2020

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

Jaya Bhushan, Joshua B Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J Lenschow, Herbert W Virgin, L David Sibley

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. When ISG15 is involved in inflammation.Frontiers in immunology · 2026
    Review
  5. The role of autophagy in protozoan infections.Frontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Susceptibility ofmBio · 2024
    Article
  15. Article
  16. Mutual regulations betweenFrontiers in immunology · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jaya BhushanDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Joshua B RadkeDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Yi-Chieh PerngDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Michael McallasterDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Deborah J LenschowDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA sibley@wustl.edu.ORCID 0000-0001-7110-0285
Washington University in St. Louis · US

Funding

RP5: Chemical proteomic discovery of small-molecule probes for autophagy proteinsU19AI142784 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VIRGIN, HERBERT W · 2019 to 2023
$36.9M
Genetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7M
TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6M
Molecular Basis of Human ToxoplasmosisR01AI118426 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2015 to 2024
$6.0M
REGULATION OF INFLUENZA VIRUS INFECTION BY ISG15R01AI080672 · NIAID · WASHINGTON UNIVERSITY · PI LENSCHOW, DEBORAH J · 2009 to 2021
$2.9M
NCI NIH HHS T32 CA009547NIAID NIH HHS R01 AI080672NIAID NIH HHS R01 AI118426NIAID NIH HHS U19 AI109725NIAID NIH HHS U19 AI142784NIAMS NIH HHS P30 AR073752
6 · The paper itself

Abstract

The intracellular protozoan parasite

Indexed as

A549 CellsAutophagyCytokinesHeLa CellsHost-Parasite InteractionsHumansImmunity, InnateInterferon-gammaProtein BindingToxoplasmaUbiquitinationUbiquitinsCytokinesInterferon-gammaISG15 protein, humanUbiquitinsATG5autophagyautophagy adaptorsBioIDintracellular parasitesISGylationLC3parasiteparasitophorous vacuoleubiquitinubiquitination

Identifiers

PMID33024031
PMCPMC7542356
OpenAlexW3092266534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.