Evidence map›Paper›PMID 33023972›Full record

ArticleDisease models & mechanisms2020

Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma.

Lena Marie Westermann, Lutz Fleischhauer, Jonas Vogel, Zsuzsa Jenei-Lanzl, Nataniel Floriano Ludwig, Lynn Schau, Fabio Morellini, Anke Baranowsky, Timur A Yorgan, Giorgia Di Lorenzo and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 3 countries.

Lena Marie WestermannDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Lutz FleischhauerLaboratory of Experimental Surgery and Regenerative Medicine, Clinic for General Trauma and Reconstructive Surgery, Ludwig-Maximilians University, 80336 Munich, Germany.
Jonas VogelCenter for Applied Tissue Engineering and Regenerative Medicine (Canter), University of Applied Sciences, 80533 Munich, Germany.
Zsuzsa Jenei-LanzlDr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopedic University Hospital Friedrichsheim gGmbH, 60528 Frankfurt/Main, Germany.
Nataniel Floriano LudwigPost-Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.
Lynn SchauRG Behavioral Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Fabio MorelliniRG Behavioral Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Anke BaranowskyDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Timur A YorganDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Giorgia Di LorenzoDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Michaela SchweizerCenter for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Bruna de Souza PinheiroDepartment of Genetics, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.
Nicole Ruas GuaranyOccupational Therapy Faculty, Federal University of Pelotas, 96010-610 Pelotas, Brazil.ORCID 0000-0002-7145-2528
Fernanda Sperb-LudwigDepartment of Genetics, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.ORCID 0000-0002-2460-7064
Fernanda VisioliPathology Department, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.
Thiago Oliveira SilvaPost-Graduate Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.
Jamie SoulSkeletal Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Gretl HendrickxDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
J Simon WiegertRG Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Ida V D SchwartzDepartment of Genetics, Federal University of Rio Grande do Sul, 90040-060 Porto Alegre, Brazil.
Hauke Clausen-SchaumannCenter for Applied Tissue Engineering and Regenerative Medicine (Canter), University of Applied Sciences, 80533 Munich, Germany.
Frank ZauckeDr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopedic University Hospital Friedrichsheim gGmbH, 60528 Frankfurt/Main, Germany.
Thorsten SchinkeDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sandra PohlDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany s.pohl@uke.de t.danyukova@uke.de.ORCID 0000-0001-7409-7042
Tatyana DanyukovaDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany s.pohl@uke.de t.danyukova@uke.de.ORCID 0000-0002-5449-3635
Universität Hamburg · DEUniversidade Federal do Rio Grande do Sul · BROrthopaedic University Hospital Friedrichsheim · DELudwig-Maximilians-Universität München · DENewcastle University · GBUniversidade Federal de Pelotas · BR

Funding

Versus Arthritis 22043
6 · The paper itself

Abstract

Mucolipidosis type III (MLIII) gamma is a rare inherited lysosomal storage disorder caused by mutations in

Indexed as

HomeostasisAchilles TendonAgingAnimalsCartilageCell DifferentiationChondrocytesDisease Models, AnimalExtracellular MatrixFibrillar CollagensJointsLysosomesMice, Inbred C57BLMice, KnockoutMotor ActivityMucolipidosesFibrillar CollagensTransferases (Other Substituted Phosphate Groups)CartilageExtracellular matrixJointsLysosomal enzymesMLIII gammaTendon

Identifiers

PMID33023972
PMCPMC7687858
OpenAlexW3092113237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.