Evidence map›Paper›PMID 33023621›Full record

ArticleParticle and fibre toxicology2020

Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO

A Guillard, E Gaultier, C Cartier, L Devoille, J Noireaux, L Chevalier, M Morin, F Grandin, M Z Lacroix, C Coméra and 14 more

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Subchronic Inhalation of TiOJournal of applied toxicology : JAT · 2025
    Article
  3. Review
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  12. Review
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  14. Review
  15. Article
  16. Toxic effects of titanium dioxide nanoparticles on reproduction in mammals.Frontiers in bioengineering and biotechnology · 2023
    Review
  17. Review
  18. Article
  19. Food-Grade Titanium Dioxide Induces Toxicity in the NematodeNanomaterials (Basel, Switzerland) · 2022
    Article
  20. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 3 countries.

A GuillardToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
E GaultierToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
C CartierToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
L DevoilleDepartment of materials, LNE, Trappes, France.
J NoireauxDepartment for biomedical and inorganic chemistry, LNE, Paris, France.
L ChevalierGroup Physic of Materials, GPM-UMR6634, CNRS, Rouen University, Rouen, France.
M MorinDepartment of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.
F GrandinToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
M Z LacroixINTHERES, UMR 1436 Toulouse University, INRAE, ENVT, Toulouse, France.
C ComéraToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
A CazanaveToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
A de PlaceDepartment of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.
V GayrardToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
V BachPéritox UMR-I 01 (Perinatality and Toxic Risk), Jules Verne University, Amiens, France.
K ChardonPéritox UMR-I 01 (Perinatality and Toxic Risk), Jules Verne University, Amiens, France.
N BekhtiUniversité Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, 91191, Gif-sur-Yvette, France.
K Adel-PatientUniversité Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, 91191, Gif-sur-Yvette, France.
C VayssièreDepartment of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.
P FisicaroDepartment for biomedical and inorganic chemistry, LNE, Paris, France.
N FeltinDepartment of materials, LNE, Trappes, France.
F de la FargeToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
N Picard-HagenToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
B LamasToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
E HoudeauToxalim UMR1331 (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. eric.houdeau@inrae.fr.ORCID 0000-0003-1971-9827
Université Toulouse III - Paul Sabatier · FRCentre Hospitalier Universitaire de Toulouse · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRCzech Academy of Sciences, Institute of Inorganic Chemistry · CZLaboratoire National de Métrologie et d'Essais · FRPérinatalité & Risques Toxiques · FRCentre National de la Recherche Scientifique · FRÉcole Nationale Vétérinaire de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTitanium dioxide (TiO

resultsBy ICP-MS analysis, we evidenced the presence of Ti in all placentae (basal level ranging from 0.01 to 0.48 mg/kg of tissue) and in 50% of the meconium samples (0.02-1.50 mg/kg), suggesting a materno-foetal passage of Ti. STEM-EDX observation of the placental tissues confirmed the presence of TiO

conclusionsAltogether, these results show a materno-foetal transfer of TiO

Indexed as

FemaleHumansMeconiumMetal NanoparticlesModels, BiologicalNanoparticlesPerfusionPlacentaPregnancyTitaniumTitaniumtitanium dioxideE171 food additiveFoetusHuman placentaNanoparticlesTitanium dioxide

Identifiers

PMID33023621
PMCPMC7541303
OpenAlexW3092095836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.