ArticleBMC microbiology2020
The effects of exopolysaccharides and exopolysaccharide-producing Lactobacillus on the intestinal microbiome of zebrafish (Danio rerio).
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Dietary Peanut Skin Proanthocyanidin Supplementation on Antioxidant Capacity and Intestinal Health of Juvenile American Eels (Animals : an open access journal from MDPI · 2026Article
- Species- and Level-Dependent Modulation of Growth and Skin and Intestinal Mucosal Microbiota in Rainbow Trout Fed Mushroom Stem Meals.Aquaculture nutrition · 2026Article
- Microbial exopolysaccharides as bioactive modulators of intestinal health: a systematic review.Frontiers in nutrition · 2026Review
- Yinchenhao Decoction mitigates intestinal impairment induced by high carbohydrate diet in largemouth bass (Micropterus salmoides): insights from inflammation, apoptosis, oxidative stress, tight junctions, and microbiota homeostasis.Fish physiology and biochemistry · 2024Article
- Effects of the Exopolysaccharide fromFoods (Basel, Switzerland) · 2023Article
- Dietary Inclusion of Seabuckthorn (Frontiers in physiology · 2022Article
- Dietary supplementation of exopolysaccharides fromFrontiers in immunology · 2022Article
- Host and microbiota metabolic signals in aging and longevity.Nature chemical biology · 2021Review
- Metagenomic and metatranscriptomic profiling of Lactobacillus casei Zhang in the human gut.NPJ biofilms and microbiomes · 2021Article
- Melatonin Regulates the Neurotransmitter Secretion Disorder Induced by Caffeine Through the Microbiota-Gut-Brain Axis in Zebrafish (Frontiers in cell and developmental biology · 2021Article
- Short chain fatty acids (SCFAs) improves TNBS-induced colitis in zebrafish.Current research in immunology · 2021Article
- Probiotic Yeasts andFrontiers in microbiology · 2021Article
- Sinomenine Hydrochloride Ameliorates Fish Foodborne EnteritisFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNumerous studies have reported the health-promoting effects of exopolysaccharides (EPSs) in in vitro models; however, a functional evaluation of EPSs will provide additional knowledge of EPS-microbe interactions by in vivo intestinal microbial model. In the present study, high-throughput amplicon sequencing, short-chain fatty acid (SCFAs) and intestinal inflammation evaluation were performed to explore the potential benefits of exopolysaccharides (EPSs) and EPS-producing Lactobacillus (HNUB20 group) using the healthy zebrafish (Danio rerio) model.
resultsThe results based on microbial taxonomic analysis revealed that the abundance of four genera, Ochrobactrum, Sediminibacterium, Sphingomonas and Sphingobium, were increased in the control group in comparison to HNUB20 group. Pelomonas spp. levels were significantly higher and that of the genera Lactobacillus and Brachybacterium were significantly decreased in EPS group compared with control group. PICRUSt based functional prediction of gut microbiota metabolic pathways indicated that significantly lower abundance was found for transcription, and membrane transport, whereas folding, sorting and degradation and energy metabolism had significantly higher abundance after HNUB20 treatment. Two metabolic pathways, including metabolism and endocrine functions, were more abundant in the EPS group than control group. Similar to the HNUB20 group, transcription was also decreased in the EPS group compared with the control group. However, SCFAs and immune indexes indicated EPS and HNUB20 performed limited efficacy in the healthy zebrafish.
conclusionsThe present intestinal microbial model-based study indicated that EPSs and high-yield EPS-producing Lactobacillus can shake the structure of intestinal microbiota, but cannot change SCFAs presence and intestinal inflammation.
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Registered trials
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