ArticleJournal of personalized medicine2020
Multivariate Analysis of Fecal Metabolites from Children with Autism Spectrum Disorder and Gastrointestinal Symptoms before and after Microbiota Transfer Therapy.
Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Research Progress on Bidirectional Regulation of the Microbiota-Gut-Brain Axis in Autism Spectrum Disorder Based on the Immune-Metabolic-Endocrine Interactive Network.Biomolecules · 2026Review
- Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder.Gut microbes · 2025Review
- The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits.Communications biology · 2025Article
- Approaches for Predicting the Occurrence of Challenging Behaviors in Individuals with Autism Spectrum Disorder: A Narrative Review.Journal of personalized medicine · 2025Review
- Intestinal Metabolome for Diagnosing and Prognosing Autism Spectrum Disorder in Children: A Systematic Review.Metabolites · 2025Review
- Washed microbiota transplantation: candidates for a novel strategy for ameliorating autism spectrum disorder.Frontiers in microbiology · 2025Review
- An Update on Microbial Interventions in Autism Spectrum Disorder with Gastrointestinal Symptoms.International journal of molecular sciences · 2024Review
- Article
- Bimodal distribution of intestinalGut microbes reports · 2024Article
- Role of gastrointestinal health in managing children with autism spectrum disorder.World journal of clinical pediatrics · 2023Review
- Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation.Microorganisms · 2023Review
- Age-Related Changes in Epilepsy Characteristics and Response to Antiepileptic Treatment in Autism Spectrum Disorders.Journal of personalized medicine · 2023Article
- Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder.Translational psychiatry · 2023Article
- Interconnection between Microbiota-Gut-Brain Axis and Autism Spectrum Disorder Comparing Therapeutic Options: A Scoping Review.Microorganisms · 2023Article
- Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome.International journal of molecular sciences · 2023Review
- Fecal microbial transplantation as a novel therapeutic for autism spectrum disorders: a review of the current literature.Frontiers in microbiomes · 2023Review
- Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Big Data Meets Metabolomics.The Canadian journal of chemical engineering · 2023Article
- Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis.Metabolites · 2022Article
- A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder.Journal of personalized medicine · 2022Article
- Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Fecal microbiota transplant (FMT) holds significant promise for patients with Autism Spectrum Disorder (ASD) and gastrointestinal (GI) symptoms. Prior work has demonstrated that plasma metabolite profiles of children with ASD become more similar to those of their typically developing (TD) peers following this treatment. This work measures the concentration of 669 biochemical compounds in feces of a cohort of 18 ASD and 20 TD children using ultrahigh performance liquid chromatography-tandem mass spectroscopy. Subsequent measurements were taken from the ASD cohort over the course of 10-week Microbiota Transfer Therapy (MTT) and 8 weeks after completion of this treatment. Univariate and multivariate statistical analysis techniques were used to characterize differences in metabolites before, during, and after treatment. Using Fisher Discriminant Analysis (FDA), it was possible to attain multivariate metabolite models capable of achieving a sensitivity of 94% and a specificity of 95% after cross-validation. Observations made following MTT indicate that the fecal metabolite profiles become more like those of the TD cohort. There was an 82-88% decrease in the median difference of the ASD and TD group for the panel metabolites, and among the top fifty most discriminating individual metabolites, 96% report more comparable values following treatment. Thus, these findings are similar, although less pronounced, as those determined using plasma metabolites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.