Evidence map›Paper›PMID 33023156›Full record

ReviewCells2020

Mechanistic Actions of microRNAs in Diabetic Wound Healing.

Marija Petkovic, Anja Elaine Sørensen, Ermelindo Carreira Leal, Eugenia Carvalho, Louise Torp Dalgaard

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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  20. [Research advances on the role of microRNA engineered exosomes in diabetic wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Marija PetkovicDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0003-0404-5241
Anja Elaine SørensenDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0001-7557-5376
Ermelindo Carreira LealCenter for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0003-1748-9861
Eugenia CarvalhoCenter for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Louise Torp DalgaardDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0002-3598-2775
Roskilde University · DKArkansas Children's Hospital · USUniversity of Coimbra · PT

Funding

The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI SWINDLE, TAREN · 2016 to 2025
$20.7M
RESOURCE CORE 3: ANALYTICAL COREP30AG028718 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI WEI, JEANNE Y · 2011 to 2015
$5.1M
NIA NIH HHS P30 AG028718NIGMS NIH HHS P20 GM109096
6 · The paper itself

Abstract

Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18-25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.

Indexed as

Diabetes MellitusHumansMicroRNAsWound HealingMicroRNAschronic woundsdiabetic wound healinginflammationproliferationremodelingtissue and circulating microRNAstissue regeneration

Identifiers

PMID33023156
PMCPMC7601058
OpenAlexW3090331431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.