Evidence map›Paper›PMID 33023106›Full record

ArticleMolecules (Basel, Switzerland)2020

Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (

Khanh-Van Ho, Anuradha Roy, Sarah Foote, Phuc H Vo, Namrita Lall, Chung-Ho Lin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Novel Insights into the Biological Activity ofMolecules (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Antimicrobial, Antioxidant, and Cytotoxic Activities ofAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Khanh-Van HoCenter for Agroforestry, School of Natural Resources, University of Missouri, Columbia, MI 65211, USA.ORCID 0000-0002-5656-2833
Anuradha RoyHigh Throughput Screening Laboratory, University of Kansas, Lawrence, KS 66047, USA.
Sarah FooteCEVA Biomune, Lenexa, KS 66215, USA.
Phuc H VoCenter for Agroforestry, School of Natural Resources, University of Missouri, Columbia, MI 65211, USA.
Namrita LallCenter for Agroforestry, School of Natural Resources, University of Missouri, Columbia, MI 65211, USA.
Chung-Ho LinCenter for Agroforestry, School of Natural Resources, University of Missouri, Columbia, MI 65211, USA.
University of Missouri · USCan Tho University · VNUniversity of Kansas · USUniversity of Pretoria · ZA

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Missouri Department of Agriculture Specialty Crop Block Grant Program 16SCBGPMO0003NIGMS NIH HHS P20 GM113117USDA/ARS Dale Bumpers Small Farm Research Center Agreement number 58-6020-6-001
6 · The paper itself

Abstract

Our recent studies have demonstrated multiple health-promoting benefits from black walnut kernels. These biological functions of black walnuts are likely associated with their bioactive constituents. Characterization of phenolic compounds found in black walnut could point out underexplored bioactive activities of black walnut extracts and promote the development of novel applications of black walnut and its by-products. In the present study, we assessed bioactivity profiles of phenolic compounds identified in the kernels of black walnuts using a high-throughput screening (HTS) approach. Black walnut phenolic compounds were evaluated in terms of their total antioxidant capacity, antioxidant response element (ARE) induction, and anticancer activities. The anticancer activities were identified by evaluating the effects of the phenolic compounds on the growth of the tumorigenic alveolar epithelial cells (A549) and non-tumorigenic lung fibroblast cells (MRC-5). Out of 16 phenolic compounds tested, several compounds (penta-

Indexed as

Antineoplastic AgentsAntioxidantsCell DeathCell ProliferationHep G2 CellsHigh-Throughput Screening AssaysHumansInhibitory Concentration 50JuglansPhenolsResponse ElementsAntineoplastic AgentsAntioxidantsPhenolsantioxidant response elementpenta-O-galloyl-β-d-glucosepolyphenol

Identifiers

PMID33023106
PMCPMC7583942
OpenAlexW3091422251

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.