Evidence map›Paper›PMID 33023100›Full record

ArticleCells2020

Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice.

Que T La, Binhai Ren, Grant J Logan, Sharon C Cunningham, Neeta Khandekar, Najah T Nassif, Bronwyn A O'Brien, Ian E Alexander, Ann M Simpson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  6. Novel vectors and approaches for gene therapy in liver diseases.JHEP reports : innovation in hepatology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Que T LaSchool of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Binhai RenSchool of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Grant J LoganGene Therapy Research Unit, Children's Medical Research Institute and Children's Hospital at Westmead, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, 214 Hawkesbury Rd, Westmead, NSW 2145, Australia.ORCID 0000-0001-9365-342X
Sharon C CunninghamGene Therapy Research Unit, Children's Medical Research Institute and Children's Hospital at Westmead, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, 214 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Neeta KhandekarGene Therapy Research Unit, Children's Medical Research Institute and Children's Hospital at Westmead, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, 214 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Najah T NassifSchool of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.ORCID 0000-0003-2675-8322
Bronwyn A O'BrienSchool of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
Ian E AlexanderGene Therapy Research Unit, Children's Medical Research Institute and Children's Hospital at Westmead, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, 214 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Ann M SimpsonSchool of Life Sciences, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
University of Technology Sydney · AUChildren's Medical Research Institute · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (

Indexed as

AnimalsDiabetes Mellitus, ExperimentalGenetic TherapyHumansInsulinMiceMice, Inbred NODInsulinadeno-associated viral vectordiabetesgene therapylivertransposon

Identifiers

PMID33023100
PMCPMC7600325
OpenAlexW3091263046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.