Evidence map›Paper›PMID 33023061›Full record

ReviewInternational journal of molecular sciences2020

Advances in D-Amino Acids in Neurological Research.

James M Seckler, Stephen J Lewis

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Can bacteria control the human brain?Communicative & integrative biology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. International journal of molecular sciences · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

James M SecklerDepartment Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Stephen J LewisDepartment Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA.
Case Western Reserve University · US

Funding

Optimization of novel thioesters as a therapeutic strategy for combating opioid overdoses and abuseU01DA051373 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI LEWIS, STEPHEN JOHN · 2020 to 2022
$1.5M
NIDA NIH HHS U01 DA051373
6 · The paper itself

Abstract

D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer's disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.

Indexed as

Alzheimer DiseaseAmino AcidsBrainBrain ChemistryHumansN-MethylaspartateReceptors, N-Methyl-D-AspartateSchizophreniaAmino AcidsN-MethylaspartateReceptors, N-Methyl-D-AspartateAlzheimerbraind-amino acidsneurological disordersN-methyl-D-aspartate (NMDA) receptorschizophrenia

Identifiers

PMID33023061
PMCPMC7582301
OpenAlexW3090290056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.