Evidence map›Paper›PMID 33022980›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes.

Joan J Soldevila-Barreda, Kehinde B Fawibe, Maria Azmanova, Laia Rafols, Anaïs Pitto-Barry, Uche B Eke, Nicolas P E Barry

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.Chembiochem : a European journal of chemical biology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Joan J Soldevila-BarredaSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UK.
Kehinde B FawibeDepartment of Chemistry, University of Ilorin, Ilorin P.M.B 1515, Nigeria.ORCID 0000-0003-0947-9380
Maria AzmanovaSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UK.ORCID 0000-0002-6800-3772
Laia RafolsSchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UK.ORCID 0000-0002-2159-9636
Anaïs Pitto-BarrySchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UK.ORCID 0000-0001-5100-0922
Uche B EkeDepartment of Chemistry, University of Ilorin, Ilorin P.M.B 1515, Nigeria.ORCID 0000-0003-4119-2937
Nicolas P E BarrySchool of Chemistry and Biosciences, University of Bradford, Bradford BD1 7DP, UK.
University of Bradford · GBUniversity of Ilorin · NG

Funding

Academy of Medical Sciences SBF003\1170The Royal Society UF150295
6 · The paper itself

Abstract

The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD

Indexed as

Antineoplastic AgentsCatalysisCell Line, TumorCell SurvivalCisplatinGlutathioneHumansIndolesInhibitory Concentration 50KineticsMolecular ConformationNADProton Magnetic Resonance SpectroscopySolutionsSpectrophotometry, UltravioletAntineoplastic AgentsCisplatinGlutathioneindoleIndolesNADSolutionsanticancerbioinorganic chemistrycatalytic drugshalf-sandwich complexesIndole

Identifiers

PMID33022980
PMCPMC7583056
OpenAlexW3090007471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.