ReviewMolecules (Basel, Switzerland)2020
Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 154 citations in OpenAlex.
- Nanocarrier-Enabled Delivery of Glucosinolates for Skin Cancer Prevention and Therapy.The AAPS journal · 2026Review
- Volatile Organic Compounds Emitted by Fungi Have Substantial Effects on Growth and Disease Resistance in Arabidopsis thaliana.Plant, cell & environment · 2026Article
- Host Rejection of the White Mustard (Sinapis alba) by a Major Oilseed Rape Pest Is Driven by the Avoidance of Sinalbin.Journal of chemical ecology · 2026Article
- Unlocking translational control of specialized metabolism in plants through 5'UTR structure.Science advances · 2026Article
- Glucosinolate Derivatives: Emerging Anti-Inflammatory Agents.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Isothiocyanate based bio-nano formulation for crop protection: mechanistic insights into antifungal action against multi-host phytopathogens.World journal of microbiology & biotechnology · 2026Article
- Structural basis of glucosinolate recognition and transport by plant GTR1.Cell discovery · 2026Article
- Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding.BMC plant biology · 2026Article
- Integrating Metabolic and Gene Expression Profiling of Glucosinolate Biosynthesis Under Drought Stress inInternational journal of molecular sciences · 2026Article
- Mustard derived compounds as insecticides and modulators of human metabolism.Scientific reports · 2026Article
- Study of Extracts ofACS omega · 2025Article
- Review
- The role of cytokinin receptors in Arabidopsis thaliana seed development and how they affect the metabolomic profile.Planta · 2025Article
- Distribution of glucosinolates and antioxidants in different leaf-layers of Kale (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Application of Microorganisms for the Valorization of Side-Products of Rapeseed De-Oiling.Biomolecules · 2025Review
- The Multifaceted Health Benefits of Broccoli-A Review of Glucosinolates, Phenolics and Antimicrobial Peptides.Molecules (Basel, Switzerland) · 2025Review
- Brassicaceae Isothiocyanate-Mediated Alleviation of Soil-Borne Diseases.Plants (Basel, Switzerland) · 2025Review
- Glucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention.Foods (Basel, Switzerland) · 2025Review
- Synthesis of ω-Methylsulfinyl- and ω-Methylsulfonylalkyl Glucosinolates.Molecules (Basel, Switzerland) · 2025Article
- The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice.Foods (Basel, Switzerland) · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Glucosinolates (GSLs) are secondary plant metabolites abundantly found in plant order Brassicales. GSLs are constituted by an S-β-d-glucopyrano unit anomerically connected to O-sulfated (Z)-thiohydroximate moiety. The side-chain of the O-sulfate thiohydroximate moiety, which is derived from a different amino acid, contributes to the diversity of natural GSL, with more than 130 structures identified and validated to this day. Both the structural diversity of GSL and their biological implication in plants have been biochemically studied. Although chemical syntheses of GSL have been devised to give access to these secondary metabolites, direct extraction from biomass remains the conventional method to isolate natural GSL. While intact GSLs are biologically inactive, various products, including isothiocyanates, nitriles, epithionitriles, and cyanides obtained through their hydrolysis of GSLs, exhibit many different biological activities, among which several therapeutic benefits have been suggested. This article reviews natural occurrence, accessibility via chemical, synthetic biochemical pathways of GSL, and the current methodology of extraction, purification, and characterization. Structural information, including the most recent classification of GSL, and their stability and storage conditions will also be discussed. The biological perspective will also be explored to demonstrate the importance of these prominent metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.