Evidence map›Paper›PMID 33022929›Full record

ReviewBioengineering (Basel, Switzerland)2020

Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering.

Michael Nguyen-Truong, Yan Vivian Li, Zhijie Wang

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  18. Biomimetic design of bioartificial scaffolds for theFrontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael Nguyen-TruongSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-1941-783X
Yan Vivian LiSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-8009-9773
Zhijie WangSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-9551-516X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine.

Indexed as

biomechanicsheart failureleft/right ventriclemechanobiologyregenerative therapy

Identifiers

PMID33022929
PMCPMC7711753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.