Evidence map›Paper›PMID 33022889›Full record

ArticleCancer medicine2020

Age-specific prevalence and determinants of depression in long-term breast cancer survivors compared to female population controls.

Daniela Doege, Melissa S Y Thong, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Ron Pritzkuleit, Annika Waldmann, Sylke R Zeissig and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025
    Article
  5. Article
  6. Article
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  8. Article
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  12. Breast cancer survivors with pain: an examination of the relationships between body mass index, physical activity, and symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  13. Article
  14. Related Factors with Depression and Anxiety in Mastectomized Women Breast Cancer Survivors.International journal of environmental research and public health · 2023
    Article
  15. Article
  16. Review
  17. The Key Role of Emotional Repair and Emotional Clarity on Depression among Breast Cancer Survivors.International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Daniela DoegeUnit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-7499-5376
Melissa S Y ThongUnit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6987-705X
Lena Koch-GallenkampDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7290-906X
Lina JansenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-8004-4940
Heike BertramCancer Registry of North Rhine-Westphalia, Bochum, Germany.
Andrea EberleBremen Cancer Registry, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.ORCID 0000-0003-4195-5236
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.ORCID 0000-0001-8759-4371
Ron PritzkuleitCancer Registry of Schleswig-Holstein, Lübeck, Germany.
Annika WaldmannHamburg Cancer Registry, Hamburg, Germany.ORCID 0000-0002-5909-9936
Sylke R ZeissigCancer Registry of Rhineland-Palatinate, Mainz, Germany.ORCID 0000-0002-0743-6128
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6129-1572
Volker ArndtUnit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
German Cancer Research Center · DEBochum University of Applied Sciences · DEIndependent Centre for Privacy Protection · DEKrebsregister Saarland · DELeibniz Institute for Prevention Research and Epidemiology - BIPS · DENational Cancer Registry · IEUniversity Cancer Center Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is more prevalent in breast cancer (BC) survivors than in the general population. However, little is known about depression in long-term survivors. Study objectives were: (1) to compare the age-specific prevalence of depressive symptoms (a) in BC survivors vs female population controls, (b) in disease-free BC survivors vs BC survivors with self-reported recurrence vs controls, and (2) to explore determinants of depression in BC survivors.

methodsAbout 3010 BC survivors (stage I-III, 5-16 years post-diagnosis), and 1005 population controls were recruited in German multi-regional population-based studies. Depression was assessed by the Geriatric Depression Scale-15. Prevalence of mild/severe and severe depression only were estimated via logistic regression, controlling for age and education. Multinomial logistic regression was used to explore determinants of mild and severe depression.

resultsCompared with population controls, BC survivors were more likely to report mild/severe depression (30.4% vs 23.8%, p = .0003), adjusted for age and education. At all age groups <80 years, prevalence of both mild/severe and severe depression only was significantly higher in BC survivors, while BC survivors ≥80 years reported severe depression less frequently than controls. BC survivors with recurrence reported significantly higher prevalence of mild/severe depression than disease-free survivors and controls, but prevalence in disease-free survivors and controls was comparable. Age, income, living independently, recurrence, and BMI were significant determinants of mild depression in BC survivors. Age, education, employment, income, recurrence, and BMI were significant determinants of severe depression.

conclusionsLong-term BC survivors <80 years report significantly higher prevalence of depressive symptoms than controls, which might be explained by recurrence and individual factors. The findings suggest that depression in BC survivors is common, and even more after BC recurrence. Clinicians should routinize screening and normalize referral to psychological care.

Indexed as

AdultAgedAged, 80 and overAge DistributionAge FactorsBody Mass IndexBreast NeoplasmsCancer SurvivorsCase-Control StudiesDepressionDisease-Free SurvivalFemaleGermanyHumansMiddle AgedNeoplasm Recurrence, Localage factorsbreast cancerdepressionlong-term cancer survivorsmental healthpopulation health

Identifiers

PMID33022889
PMCPMC7666751
OpenAlexW3091850729

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.