ArticleHuman brain mapping2021
Computing and visualising intra-voxel orientation-specific relaxation-diffusion features in the human brain.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Informed Dictionary-Guided Monte Carlo Inversion for Robust and Reproducible Multidimensional MRI.Magnetic resonance in medicine · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI.Frontiers in neuroscience · 2026Article
- Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: Overfitting or meaningful parameter?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer's disease.Brain communications · 2025Article
- In vivo rat brain mapping of multiple gray matter water populations using nonparametric D(ω)-RNMR in biomedicine · 2025Article
- T1 relaxation and axon fibre configuration in human white matter.NMR in biomedicine · 2024Article
- Variability of multidimensional diffusion-relaxation MRI estimates in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mapping astrogliosis in the individual human brain using multidimensional MRI.Brain : a journal of neurology · 2023Article
- Differentiation of white matter histopathology using b-tensor encoding and machine learning.PloS one · 2023Article
- Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain communications · 2023Article
- Dual-encoded magnetization transfer and diffusion imaging and its application to tract-specific microstructure mapping.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Nonparametric 5D D-RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.NeuroImage · 2022Review
- Accelerating joint relaxation-diffusion MRI by integrating time division multiplexing and simultaneous multi-slice (TDM-SMS) strategies.Magnetic resonance in medicine · 2022Article
- Editorial: Capturing Biological Complexity and Heterogeneity Using Multidimensional MRI.Frontiers in physics · 2022Article
- COnstrained Reference frame diffusion TEnsor Correlation Spectroscopic (CORTECS) MRI: A practical framework for high-resolution diffusion tensor distribution imaging.Frontiers in neuroscience · 2022Article
- Distortion-Free Diffusion Imaging Using Self-Navigated Cartesian Echo-Planar Time Resolved Acquisition and Joint Magnitude and Phase Constrained Reconstruction.IEEE transactions on medical imaging · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 6 countries.
Funding
Abstract
Diffusion MRI techniques are used widely to study the characteristics of the human brain connectome in vivo. However, to resolve and characterise white matter (WM) fibres in heterogeneous MRI voxels remains a challenging problem typically approached with signal models that rely on prior information and constraints. We have recently introduced a 5D relaxation-diffusion correlation framework wherein multidimensional diffusion encoding strategies are used to acquire data at multiple echo-times to increase the amount of information encoded into the signal and ease the constraints needed for signal inversion. Nonparametric Monte Carlo inversion of the resulting datasets yields 5D relaxation-diffusion distributions where contributions from different sub-voxel tissue environments are separated with minimal assumptions on their microscopic properties. Here, we build on the 5D correlation approach to derive fibre-specific metrics that can be mapped throughout the imaged brain volume. Distribution components ascribed to fibrous tissues are resolved, and subsequently mapped to a dense mesh of overlapping orientation bins to define a smooth orientation distribution function (ODF). Moreover, relaxation and diffusion measures are correlated to each independent ODF coordinate, thereby allowing the estimation of orientation-specific relaxation rates and diffusivities. The proposed method is tested on a healthy volunteer, where the estimated ODFs were observed to capture major WM tracts, resolve fibre crossings, and, more importantly, inform on the relaxation and diffusion features along with distinct fibre bundles. If combined with fibre-tracking algorithms, the methodology presented in this work has potential for increasing the depth of characterisation of microstructural properties along individual WM pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.