ArticleEuropean heart journal2020
Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Association of cognitive impairment and peripheral artery disease (PAD): A systematic review.Vascular medicine (London, England) · 2025Pooled it
- Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway.Journal of translational medicine · 2023Pooled it
- Cardiovascular disease risk models and dementia or cognitive decline: a systematic review.Frontiers in aging neuroscience · 2023Pooled it
- Pooled it
- Cardiometabolic risk factors and brain age: a meta-analysis to quantify brain structural differences related to diabetes, hypertension, and obesity.Journal of psychiatry & neuroscience : JPNPooled it
- Systemic and proximal tubule specific knockout ofPhysiological genomics · 2026Article
- Two steps forward, one step back: cohort shifts in cognitive function trajectories in aging European populations.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.medRxiv : the preprint server for health sciences · 2026Article
- Review
- How to measure and model cardiovascular aging.Cardiovascular research · 2025Review
- A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers.Alzheimer's research & therapy · 2025Article
- Causal cardiovascular risk factors for dementia: insights from observational and genetic studies.Cardiovascular research · 2025Review
- Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes.Molecular psychiatry · 2025Article
- Amyloid-beta metabolism in age-related neurocardiovascular diseases.European heart journal · 2025Review
- Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts.Frontiers in public health · 2025Article
- Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure.Circulation research · 2024Review
- Diagnostic accuracy of BASIC-Q for detection of cognitive impairment in a primary care setting - a cross-validation study.BMC geriatrics · 2024Article
- Observational
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDementia is a major global challenge for health and social care in aging populations. A third of all dementia may be preventable due to cardiovascular risk factors. Intensive multi-domain intervention trials targeting primarily cardiovascular risk factors show improved cognitive function in people at risk. Such interventions will, however, be expensive to implement in all individuals at risk and will represent unrealistic economic tasks for most societies. Therefore, a risk score identifying high-risk individuals is warranted. METHODS AND
resultsIn 61 664 individuals from two prospective cohorts of the Danish general population, we generated 10-year absolute risk scores for all-cause dementia from cardiovascular risk factors and genetics. In both sexes, 10-year absolute risk of all-cause dementia increased with increasing age, number of apolipoprotein E (APOE) ɛ4 alleles, number of genome-wide association studies (GWAS) risk alleles, and cardiovascular risk factors. The highest 10-year absolute risks of all-cause dementia seen in smoking women with diabetes, low education, APOE ɛ44 genotype, and 22-31 GWAS risk alleles were 6%, 23%, 48%, and 66% in those aged 50-59, 60-69, 70-79, and 80-100, respectively. Corresponding values for men were 5%, 19%, 42%, and 60%, respectively.
conclusionTen-year absolute risk of all-cause dementia increased with age, APOE ɛ4 alleles, GWAS risk alleles, diabetes, low education, and smoking in both women and men. Ten-year absolute risk charts for dementia will facilitate identification of high-risk individuals, those who likely will benefit the most from an early intervention against cardiovascular risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.