Evidence map›Paper›PMID 33022701›Full record

ArticleThe American journal of clinical nutrition2020

Prospective study of a diabetes risk reduction diet and the risk of breast cancer.

Jae H Kang, Cheng Peng, Jinnie J Rhee, Maryam S Farvid, Walter C Willett, Frank B Hu, Bernard A Rosner, Rulla Tamimi, A Heather Eliassen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jae H KangChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Cheng PengChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Jinnie J RheeDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maryam S FarvidDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Walter C WillettDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Frank B HuChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Bernard A RosnerChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Rulla TamimiChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
A Heather EliassenChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USStanford University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Assessing the role of androgens in breast cancer riskR01CA166666 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HANKINSON, SUSAN E · 2012 to 2015
$1.7M
Toward optimizing diabetes care in persons with chronic kidney diseaseK01DK110221 · NIDDK · STANFORD UNIVERSITY · PI RHEE, JINNIE J. · 2017 to 2021
$772k
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA166666NCI NIH HHS U01 CA176726NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA186107NIDDK NIH HHS K01 DK110221
6 · The paper itself

Abstract

backgroundHyperinsulinemia and higher insulin-like growth factors may increase breast cancer risk. We evaluated a diabetes risk reduction diet (DRRD) and breast cancer risk.

objectivesWe prospectively evaluated the association between adherence to a DRRD and the incidence of breast cancer.

methodsWe followed 88,739 women from the Nurses' Health Study (NHS; 1980-2016) and 93,915 women from the NHSII (1991-2017). Incident breast cancer cases (n = 11,943) were confirmed with medical records, and subtypes were determined by tissue microarray data and pathology reports. Information on diet and breast cancer risk factors was repeatedly ascertained in follow-up questionnaires. A DRRD score was derived with 9 factors: lower glycemic index of diet; lower intakes of trans fat, sugar-sweetened beverages/fruit juices, and red/processed meat; higher intakes of cereal fiber, coffee, nuts, and whole fruits; and a higher ratio of polyunsaturated to saturated fat (score range: 9-45). Multivariable-adjusted hazard ratios (MVHRs) and 95% CIs were calculated with Cox proportional hazards models.

resultsBeing in the highest compared with the lowest DRRD adherence quintile was associated with a modestly lower breast cancer risk (MVHRQ5vsQ1: 0.89; 95% CI: 0.84, 0.95; P-trend = 0.0002); this was attenuated after adjusting for weight change since age 18 y (MVHRQ5vsQ1: 0.92; 95% CI: 0.87, 0.98; P-trend = 0.01). The inverse association was strongest among women with current BMI < 25 kg/m2 (MVHRQ5vsQ1: 0.89; 95% CI: 0.81, 0.98; P-trend = 0.004; P-interaction = 0.04). Among tumor molecular subtypes, the strongest inverse association was observed with basal-type tumors (MVHRQ5vsQ1: 0.67; 95% CI: 0.45, 1.01; P-trend = 0.04).

conclusionsGreater DRRD-adherence was associated with lower breast cancer risk, likely mediated by less weight gain with a DRRD; however, independently of weight change, DRRD-adherence was modestly associated with lower breast cancer risk, particularly among lean women.

Indexed as

DietAgedBreast NeoplasmsDiabetes Mellitus, Type 2FemaleHumansMiddle AgedProportional Hazards ModelsRisk Reduction Behaviorbreast cancerdietepidemiologyrisk factorstumor subtypes

Identifiers

PMID33022701
PMCPMC7727476
OpenAlexW3091808500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.