Evidence map›Paper›PMID 33022693›Full record

ArticleThe American journal of clinical nutrition2020

Fruit and vegetable intake and risk of frailty in women 60 years old or older.

Teresa T Fung, Ellen A Struijk, Fernando Rodriguez-Artalejo, Walter C Willett, Esther Lopez-Garcia

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Total magnesium intake and risk of frailty in older women.Journal of cachexia, sarcopenia and muscle · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Benefits of Mediterranean and Japanese Diets among Nurses: A Scoping Literature Review.Endocrine, metabolic & immune disorders drug targets · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Teresa T FungDepartment of Nutrition, Simmons University, Boston, MA, USA.
Ellen A StruijkDepartment of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-Idi Paz, Madrid, Spain.
Fernando Rodriguez-ArtalejoDepartment of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-Idi Paz, Madrid, Spain.
Walter C WillettChanning Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Esther Lopez-GarciaDepartment of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-Idi Paz, Madrid, Spain.
Madrid Institute for Advanced Studies · ESBrigham and Women's Hospital · USCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESSimmons University · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

backgroundPrior research has suggested that the antioxidative and anti-inflammatory potential of fruits and vegetables may ameliorate aging-related frailty.

objectiveWe sought to prospectively examine the association between fruit and vegetable intake and incident frailty in older women.

designWe followed 78,366 nonfrail women aged ≥60 y from the Nurses' Health Study from 1990 to 2014. In this analysis, the primary exposure was the intake of total fruits and vegetables, assessed with an FFQ administered 6 times during follow-up. Frailty was defined as having ≥3 of the following 5 criteria from the FRAIL scale: fatigue, poor strength, low aerobic capacity, having ≥5 illnesses, and ≥5% weight loss. Cox models adjusted for potential confounders were used to estimate HRs and 95% CIs for the association between fruit and vegetable intake and incident frailty.

resultsIn total, 12,434 (15.9%) incident frailty cases were accrued during follow-up. Total fruit and vegetable intakes were associated with a lower risk of frailty (adjusted HR comparing 7+ servings/d compared with <3 servings/d: 0.92; 95% CI: 0.85, 0.99). The inverse association appeared to be stronger for those with physical activity above the median (P-interaction < 0.05). Among physically active women, compared with those who consumed <3 servings/d, the HR for 7+ servings/d was 0.68 (95% CI: 0.57, 0.81).

conclusionHigher fruit and vegetable intake was associated with a lower risk of frailty in this cohort of US women aged ≥60 y. Because of limited evidence on intakes of fruits and vegetables and the development of frailty, more data are needed to confirm our results.

Indexed as

DietFruitVegetablesAgedFemaleFrailtyHumansMiddle Agedelderlyfrailtyfruitsnutritionvegetableswomen

Identifiers

PMID33022693
PMCPMC7727483
OpenAlexW3091871208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.