ArticleNeurobiology of aging2020
Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Corpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors.GeroScience · 2026Article
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy.Molecular neurodegeneration · 2026Article
- Evaluating regional and global diffusion measures as biomarkers for vascular contributions to cognitive impairment and dementia.Cerebral circulation - cognition and behavior · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Associations of cholinergic white matter hyperintensity volume with cognitive decline and incident dementia in older adults: a cohort study.BMC geriatrics · 2025Article
- Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.BMC veterinary research · 2025Article
- Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample.Alzheimer's research & therapy · 2025Article
- Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer's disease continuum.Metabolic brain disease · 2025Article
- Plasma NfL and GFAP for predicting VCI and related brain changes in community and clinical cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.Brain structure & function · 2025Article
- Brain mechanical properties predict longitudinal cognitive change in aging and Alzheimer's disease.Neurobiology of aging · 2025Article
- Early subacute frontal callosal microstructure and language outcomes after stroke.Brain communications · 2025Article
- Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.bioRxiv : the preprint server for biology · 2024Article
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- Choir singing is associated with enhanced structural connectivity across the adult lifespan.Human brain mapping · 2024Article
- Vascular risk, gait, behavioral, and plasma indicators of VCID.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Diffusion kurtosis imaging of brain white matter alteration in patients with coronary artery disease based on the TBSS method.Frontiers in aging neuroscience · 2024Article
- Association Between Anatomic and Clinical Indicators of Injury Severity After Moderate-Severe Traumatic Brain Injury: A Pilot Study Using Multiparametric Magnetic Resonance Imaging.Neurotrauma reports · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid positron emission tomography, and at least one clinical follow-up. We used mixed-effect models to evaluate the prognostic ability of fractional anisotropy of the genu of the corpus callosum (FA-Genu), as a cerebrovascular disease marker, for predicting cognitive decline along with AD biomarkers. We contrasted the value of white matter hyperintensities, a traditional cerebrovascular disease marker as well as FA in the hippocampal cingulum bundle with the FA-Genu models. FA-Genu significantly predicted cognitive decline even after accounting for AD biomarkers. WMH was not associated with cognitive decline in the model with both WMH and FA-Genu. DTI specifically FA-Genu provides unique complementary information to AD biomarkers and has significant utility for prediction of cognitive decline in MCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.