Evidence map›Paper›PMID 33022472›Full record

ArticleCancer epidemiology2020

Ovarian cancer in California: Guideline adherence, survival, and the impact of geographic location, 1996-2014.

Carolina Villanueva, Jenny Chang, Argyrios Ziogas, Robert E Bristow, Verónica M Vieira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Homologous Recombination Deficiency and Survival in Ovarian High-Grade Serous Carcinoma by Self-Reported Race.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  2. Review
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  6. Geographic differences in community oncology provider and practice location characteristics in the central United States.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carolina VillanuevaProgram in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Anteater Instruction & Research Building, 653 East Peltason Drive, Irvine, CA, 92697, USA. Electronic address: hcvillan@uci.edu.
Jenny ChangDepartment of Medicine, School of Medicine, University of California, 205 Irvine Hall, Irvine, CA, 92697, USA. Electronic address: jjchang@uci.edu.
Argyrios ZiogasDepartment of Medicine, School of Medicine, University of California, 205 Irvine Hall, Irvine, CA, 92697, USA. Electronic address: aziogas@uci.edu.
Robert E BristowChao Family Comprehensive Cancer Center, Orange, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine School of Medicine, 333 City Boulevard West, Ste 1400, Orange, CA, 92868, USA. Electronic address: rbristow@uci.edu.
Verónica M VieiraProgram in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Anteater Instruction & Research Building, 653 East Peltason Drive, Irvine, CA, 92697, USA; Chao Family Comprehensive Cancer Center, Orange, CA, USA. Electronic address: vvieira@uci.edu.

Funding

Spatiotemporal Analysis of Disparities in Ovarian Cancer Treatment and SurvivalR01MD009697 · NIMHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRISTOW, ROBERT EDWARD, VIEIRA, VERONICA M · 2016 to 2020
$1.9M
NIMHD NIH HHS R01 MD009697
6 · The paper itself

Abstract

backgroundEvidence suggests that geographic location may independently contribute to ovarian cancer survival. We aimed to investigate how the association between residential location and ovarian cancer-specific survival in California varies by race/ethnicity and socioeconomic status.

methodsAdditive Cox proportional hazard models were used to predict hazard ratios (HRs) and 95% confidence intervals (CI) for the association between geographic location throughout California and survival among 29,844 women diagnosed with epithelial ovarian cancer between 1996 and 2014. We conducted permutation tests to determine a global P-value for significance of location. Adjusted analyses considered distance traveled for care, distance to closest high-quality-of-care hospital, and receipt of National Comprehensive Cancer Network guideline care. Models were also stratified by stage, race/ethnicity, and socioeconomic status.

resultsLocation was significant in unadjusted models (P = 0.009 among all stages) but not in adjusted models (P = 0.20). HRs ranged from 0.81 (95% CI: 0.70, 0.93) in Southern Central Valley to 1.41 (95% CI: 1.15, 1.73) in Northern California but were attenuated after adjustment (maximum HR = 1.17, 95% CI: 1.08, 1.27). Better survival was generally observed for patients traveling longer distances for care. Associations between survival and proximity to closest high-quality-of-care hospitals were null except for women of lowest socioeconomic status living furthest away (HR = 1.22, 95% CI: 1.03, 1.43).

conclusionsOverall, geographic variations observed in ovarian cancer-specific survival were due to important predictors such as receiving guideline-adherent care. Improving access to expert care and ensuring receipt of guideline-adherent treatment should be priorities in optimizing ovarian cancer survival.

Indexed as

Social ClassCaliforniaFemaleHumansMiddle AgedOvarian NeoplasmsRetrospective StudiesGeographic disparitiesOvarian cancerSpatial locationSurvival

Identifiers

PMID33022472
PMCPMC7710533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.