Evidence map›Paper›PMID 33022285›Full record

ArticleJournal of theoretical biology2021

Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons.

Nirvik Sinha, C J Heckman, Yuan Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of theoretical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nirvik SinhaNorthwestern Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, 320 E Superior Street, Morton 1-645, Chicago, IL 60611-3010, USA; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave., Suite 1100, Chicago, IL 60611, USA.
C J HeckmanNorthwestern Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, 320 E Superior Street, Morton 1-645, Chicago, IL 60611-3010, USA; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave., Suite 1100, Chicago, IL 60611, USA; Department of Physiology, Feinberg School of Medicine, Northwestern University, 310 E. Superior Street Morton 5-660, Chicago, IL 60611, USA.
Yuan YangNorthwestern Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, 320 E Superior Street, Morton 1-645, Chicago, IL 60611-3010, USA; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave., Suite 1100, Chicago, IL 60611, USA; Stephenson School of Biomedical Engineering, University of Oklahoma, 4502 E. 41st St, Tulsa, OK 74135, USA; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA. Electronic address: yuan.yang-2@ou.edu.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Mechanisms of electrical stimulation of a canonical motor microcircuitR01NS109552 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2018 to 2022
$2.5M
The Human Motor Output MapR01NS098509 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2016 to 2020
$2.1M
Determination of the Recruitment of Indirect Motor Pathways in Chronic Hemiparetic StrokeR21HD099710 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, YANG, YUAN · 2019 to 2020
$416k
NCATS NIH HHS UL1 TR001422NICHD NIH HHS R21 HD099710NINDS NIH HHS R01 NS098509NINDS NIH HHS R01 NS109552
6 · The paper itself

Abstract

A major challenge in understanding spike-time dependent information encoding in the neural system is the non-linear firing response to inputs of the individual neurons. Hence, quantitative exploration of the putative mechanisms of this non-linear behavior is fundamental to formulating the theory of information transfer in the neural system. The objective of this simulation study was to evaluate and quantify the effect of slowly activating outward membrane current, on the non-linearity in the output of a one-compartment Hodgkin-Huxley styled neuron. To evaluate this effect, the peak conductance of the slow potassium channel (g

Indexed as

NeuronsPotassium ChannelsModels, NeurologicalPotassium ChannelsCross-frequency couplingHodgkin-Huxley neuronSlow potassium conductanceSub-harmonic coupling

Identifiers

PMID33022285
PMCPMC7704641
OpenAlexW3090505119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.